Airway Responsiveness and Inflammation in Adolescent Elite Swimmers: a 3-Year Prospective Follow-up Study
1 other identifier
observational
33
1 country
1
Brief Summary
Previously the investigators have found that adolescent elite swimmers, who have been involved in competitive swimming for only a few years, have not developed respiratory symptoms, signs of airway inflammation or airway hyperresponsiveness exept for a slight increase in airway responsiveness to eucapnic voluntary hyperpnea. In the current study, the investigators will be doing a 3-year follow-up study on the swimmers studied previously.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 10, 2009
CompletedFirst Posted
Study publicly available on registry
February 11, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedFebruary 24, 2009
February 1, 2009
4 months
February 10, 2009
February 23, 2009
Conditions
Outcome Measures
Primary Outcomes (1)
Airway responsiveness to eucapnic voluntary hyperpnea and methacholine
Three years
Secondary Outcomes (1)
Airway inflammation
Three years
Study Arms (1)
Swimmers
Eligibility Criteria
Participants were all elite swimmers and part of the Danish National Swimming Association's talent program for young swimmers at the baseline study.
You may qualify if:
- Age 15-19 years
- Part of the Danish National Swimming Association's talent program for young swimmers at the baseline study
- Informed consent
You may not qualify if:
- Upper respiratory tract infection in the previous 4 weeks (visits will be postponed)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Respiratory and Allergy Research Unit, Department of Respiratory Medicine L, Bispebjerg Hospital
Copenhagen, 2400, Denmark
Related Publications (1)
Pedersen L, Lund TK, Barnes PJ, Kharitonov SA, Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol. 2008 Aug;122(2):322-7, 327.e1. doi: 10.1016/j.jaci.2008.04.041. Epub 2008 Jun 12.
PMID: 18554704BACKGROUND
Biospecimen
Blood (serum, whole blood) Exhaled breath condensate Induced sputum
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Lars Pedersen, MD PhD
Respiratory and Allergy Research Unit, Bispebjerg Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 10, 2009
First Posted
February 11, 2009
Study Start
February 1, 2009
Primary Completion
June 1, 2009
Study Completion
June 1, 2010
Last Updated
February 24, 2009
Record last verified: 2009-02