Exercise in Men With Prostate Cancer

NCT00834392 | Completed

• 1 other identifier: H2008:035
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this pilot study is to compare a walking exercise program (Exercise Group) to standard medical care (Control Group) in prostate cancer survivors receiving androgen depletion therapy (ADT). The central hypothesis of the proposed research is that the walking exercise program will have a positive impact on the bone health, health-related quality of life, and physical function of men with prostate cancer receiving ADT.

Conditions

Prostate Cancer

Outcome Measures

Primary Outcomes (1)

• bone health

  baseline, 12 months

Study Arms (2)

Control

NO INTERVENTION

Exercise

EXPERIMENTAL

Behavioral: Exercise

Interventions

Exercise BEHAVIORAL

Walking exercise

Exercise

Eligibility Criteria

• Age: 50 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• men aged 50 years or older
• diagnosed with adenocarcinoma prostate cancer
• will initiate and receive continuous ADT (luteinizing hormone releasing hormone agonist (LHRH) or combination of LHRH and anti-androgen) for at least 12 months after recruitment
• Patients will also consent to participating in the study.

You may not qualify if:

• severe cardiac disease (New York Heart Association class III or greater)
• angina
• severe osteoporosis
• uncontrolled hypertension (blood pressure \> 160/95mm Hg)
• orthostatic blood pressure drop \> 20mm Hg
• moderate to severe aortic stenosis
• acute illness or fever
• uncontrolled atrial or ventricular dysrhythmias
• uncontrolled sinus tachycardia (\> 120 beats per minute)
• uncontrolled congestive heart failure third-degree atrio-ventricular heart block, active pericarditis or myocarditis, recent embolism, thrombophlebitis, deep vein thrombosis, resting ST displacement (\> 3mm), uncontrolled diabetes, uncontrolled pain, cognitive impairment, history of falls due to balance impairment or lost of consciousness, severe neuromusculoskeletal conditions that limit their ability to perform walking exercise (including ataxia, peripheral or sensory neuropathy, unstable bone lesion, severe arthritis, pathological lower limb fractures within 6 months, lower limb amputation).

Sponsors & Collaborators

• University of Manitoba: lead
• Manitoba Medical Service Foundation: collaborator

Study Sites (1)

University of Manitoba

Winnipeg, Manitoba, R3E 0T6, Canada

Location

Related Publications (1)

• Lee CE, Leslie WD, Lau YK. A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy. BMC Cancer. 2012 Mar 21;12:103. doi: 10.1186/1471-2407-12-103.

  PMID: 22436542 DERIVED

MeSH Terms

Conditions

Prostatic Neoplasms

Interventions

Exercise

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• C. Ellen Lee, PhD, PT

  University of Manitoba

  PRINCIPAL INVESTIGATOR

• Y.K. James Lau, MD, PhD

  CancerCare Manitoba

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 2, 2009
• First Posted: February 3, 2009
• Study Start: October 1, 2008
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2010
• Last Updated: February 1, 2011

Record last verified: 2011-01

Locations

CA (1)