Pilot Project: Fast Whole-body Spect Scanning to Improve the Detection of Bone Metastases in Patients With Diagnosed Cancer

NCT00824213 | Completed

• 1 other identifier: H08-01640
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 3

Brief Summary

The investigators propose to investigate the performance of the image reconstruction software with resolution recovery correction for bone SPECT studies. The investigators estimate that in only 30 minutes, using this new technique of collimator de-blurring, one could perform a fully 3-dimensional SPECT whole-body bone study, essentially obviating the necessity for doing planar bone studies. In the scope of the proposed project, the investigators group aims to test the hypothesis that one can perform a Tc-99m whole-body SPECT study in the same time as a regular routine planar bone study, with greater localization accuracy, and greater lesion detection. To establish a "gold standard" necessary to assess the performance of the SPECT bone scans, the investigators will compare number of malignant lesions detected in patients who are proven to have metastatic skeletal bone lesions on PET F-18 whole-body scans, with whole-body Tc-99m SPECT lesions. The investigators also propose to compare the detection of SPECT scans with standard planar bone scans. This will allow for two major comparisons (a) the accuracy of SPECT bone studies compared to planar bone studies, and (b) the accuracy of SPECT bone scans compared to F-18 PET studies. Most prior studies purporting to show the superiority of F-18 bone scans to Tc-99 bone scans were done only against either planar scans or a combination of planar scans and partial SPECT studies over the spine. We anticipate that F-18 bone scans, due to the higher counting statistics of PET agents, will show more lesions than SPECT, but the exact increase in sensitivity has never been compared to whole-body SPECT scans.

Conditions

Bone Metastases

Keywords

Whole Body SPECT imaging

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Over the last 3-4 months, 60 anonymized patient studies were acquired using concurrent acquisition protocol with 20s, 15s, 10s, and 5s per view and with a total of 64 views (32 views/head). The data from these studies will be used to optimize the reconstruction process and establish the definitive reconstruction parameters to be used in the current study. We plan to accrue a total of 25 subjects with suspected bone metastases who will undergo planar bone scintigraphy, bone SPECT and a Na18F whole-body bone PET scan.

You may qualify if:

• Patients with a prior history of prostate cancer and
• clinically suspected bone metastases based on symptoms, radiological examinations or abnormal biochemistry results

You may not qualify if:

• Inability to consent to participate in the research study.
• Inability to lie supine for a period of at least 45 minutes.
• Inability to travel to the examination site to undergo the PET/CT examination.
• ECOG/WHO performance status ≥ 2

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (3)

Lions Gate Hospital

North Vancouver, British Columbia, V7L 2L7, Canada

Location

British Columbia Cancer Agency

Vancouver, British Columbia, V5Z 1L3, Canada

Location

Vancouver Coastal Health Research Institute

Vancouver, British Columbia, V5Z 3P1, Canada

Location

Study Officials

• Anna Celler, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

• Philip Cohen

  University of British Columbia

  STUDY DIRECTOR

• Francois Benard

  University of British Columbia

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: January 14, 2009
• First Posted: January 16, 2009
• Study Start: January 1, 2009
• Primary Completion: August 10, 2016
• Study Completion: August 10, 2016
• Last Updated: March 3, 2017

Record last verified: 2017-03

Locations

CA (3)