Trials Sponsors Conditions Drugs Pricing

Conditions

Rapid Eye Movement Sleep Behavior Disorder

Keywords

Rapid Eye Movement Sleep Behavior DisorderParkinson's DiseaseParkinsonian SyndromesAtypical Parkinson'sRBDPDfMRIPSPMSA

Outcome Measures

Primary Outcomes (1)

Identify the key cognitive and non-motor characteristics for early PD diagnosis
periodically performed set of clinical and imaging parameters suspected to be linked to PD to see if, as a group, these parameters could identify those at risk for motor symptoms of PD before these symptoms develop.
5 years

Secondary Outcomes (3)

Further characterize the sleep behavior patterns, olfactory function, and neurologic assessments of subjects longitudinally, over 5 years, within each group of patients.
5 years
functional MRI of the brain and eye tracking testing, identification of distinct features in PD
beginning of study and at 2 years
identify key fluid-based PD-associated molecular markers that identify disease state or progression
5 years

Study Arms (2)

1- RBD

polysomnographically diagnosed RBD patients. RBD is a sleep disorder diagnosed by a sleep lab in which the individual has muscle movements during the phase of deep sleep during which the muscles should be relaxed. Suspicion of RBD by history will be confirmed during screening.

2 - control

control: * must not have any neurological degenerative diagnosis. * must NOT have RBD. * must be able to age and/or gender-match to RBD and PD subjects already enrolled.

Eligibility Criteria

Age35 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients with polysomnographically-documented RBD, non-neurodegenerative diagnosis Age and gender matched non-RBD diagnosis, non-neurodegenerative diagnosis idiopathic PD diagnosis atypical PD diagnosis

You may qualify if:

year old men \& women

Sponsors & Collaborators

The University of Texas Health Science Center, Houston
Otherlead

Study Sites (1)

University of texas Health Science Center at Houston

Houston, Texas, 77030, United States

Biospecimen

Retention: SAMPLES WITH DNA

blood (serum)

MeSH Terms

Conditions

REM Sleep Behavior DisorderParkinson DiseaseParkinsonian Disorders

Condition Hierarchy (Ancestors)

REM Sleep ParasomniasParasomniasSleep Wake DisordersNervous System DiseasesMental DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Officials

Mya C Schiess, MD
The University fo texas Health Science Center at Houston
PRINCIPAL INVESTIGATOR

Enrollment

164 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Professor - Neurology

Study Record Dates

First Submitted

January 5, 2009

First Posted

January 6, 2009

Study Start

January 2009

Actual (reported)

RBD Longitudinal as Prognostic for PD

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

1- RBD

2 - control

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

1- RBD

2 - control

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations