NCT00817245

Brief Summary

Etiology of ICSCR is not known however recent studies regard the role of immunologic and infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of helicobacter pylori in the pathogenesis of ICSCR so perhaps treatment of h pylori have positive effect on the remission of ICSCR.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P50-P75 for phase_1

Timeline
Completed

Started Mar 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2008

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2008

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

January 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2009

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 6, 2009

Completed
Last Updated

January 6, 2009

Status Verified

January 1, 2009

Enrollment Period

7 months

First QC Date

January 1, 2009

Last Update Submit

January 5, 2009

Conditions

Central Serous Chorioretinopathy

Keywords

CSRHelicobacter pylori

Outcome Measures

Primary Outcomes (1)

  • Subretinal fluid level

Secondary Outcomes (1)

  • time of sub macular fluid absorption

Study Arms (2)

1

ACTIVE COMPARATOR

Oral Amoxicillin Capsule Metronidazole Tablet Omeprazole Capsule

Drug: omeprazole, Amoxicillin, metronidazole

2

NO INTERVENTION

No medical treatment

Interventions

omeprazole, Amoxicillin, metronidazoleDRUG

we will evaluate the effect of medication(anti h.pylori) on the remission of ICSCR

Also known as: treatment of Central serous chorioretinopathy
1

Eligibility Criteria

Age28 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • the persons who are infected with helicobacter pylori and have ICSCR

You may not qualify if:

  • history of previous eye surgery ,to have indication of laser therapy,corticosteroid therapy,pregnancy,

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Alireza JavadzadehTabriz

Tabriz, Iran

Location

Related Publications (1)

  • Lange CA, Qureshi R, Pauleikhoff L. Interventions for central serous chorioretinopathy: a network meta-analysis. Cochrane Database Syst Rev. 2025 Jun 16;6(6):CD011841. doi: 10.1002/14651858.CD011841.pub3.

    PMID: 40522203DERIVED

MeSH Terms

Conditions

Central Serous Chorioretinopathy

Interventions

OmeprazoleAmoxicillinMetronidazole

Condition Hierarchy (Ancestors)

Retinal DiseasesEye Diseases

Intervention Hierarchy (Ancestors)

2-PyridinylmethylsulfinylbenzimidazolesSulfoxidesSulfur CompoundsOrganic ChemicalsPyridinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsBenzimidazolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingAmpicillinPenicillin GPenicillinsbeta-LactamsLactamsAmidesNitroimidazolesNitro CompoundsImidazolesAzoles

Study Officials

  • Alireza Javadzadeh

    Alireza Javadzadeh

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 1, 2009

First Posted

January 6, 2009

Study Start

March 1, 2008

Primary Completion

October 1, 2008

Study Completion

January 1, 2009

Last Updated

January 6, 2009

Record last verified: 2009-01

Locations

IR(1)