The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution
Beneficial Cardiovascular Effects of Reducing Exposure to Particulate Air Pollution With a Simple Facemask
1 other identifier
interventional
15
1 country
1
Brief Summary
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia. The study objectives were to assess the potential cardiovascular benefits of reducing personal particulate air pollution exposure by wearing a facemask in healthy volunteers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
December 15, 2008
CompletedFirst Posted
Study publicly available on registry
December 17, 2008
CompletedDecember 17, 2008
December 1, 2008
Same day
December 15, 2008
December 15, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ambulatory blood pressure
During 24 hour study period
Secondary Outcomes (3)
Heart rate
During 24 hour study period
Heart rate variability
During 24 hour study period
Personal air pollution exposure
During 2 hour city centre walk
Study Arms (2)
Visit 1
EXPERIMENTAL2 hour city centre kerbside walk in Beijing China
Visit 2
EXPERIMENTAL2 hour city centre kerbside walk in Beijing China
Interventions
Subjects to wear a simple face mask for 24 hours prior to the study day and the 24 hours of the study day. They will be instructed to wear the mask as much as possible when indoors and at all times when outdoors.
Subjects will not wear a face mask to reduce their personal exposure to air pollution
Eligibility Criteria
You may qualify if:
- Healthy volunteers
You may not qualify if:
- Current smokers
- Significant occupational exposure to air pollution
- Regular medication use (except oral contraceptive pill)
- Intercurrent illness
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Edinburghlead
- Peking Union Medical Collegecollaborator
Study Sites (1)
Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Medical Union College
Beijing, China
Related Publications (1)
Langrish JP, Watts SJ, Hunter AJ, Shah AS, Bosson JA, Unosson J, Barath S, Lundback M, Cassee FR, Donaldson K, Sandstrom T, Blomberg A, Newby DE, Mills NL. Controlled exposures to air pollutants and risk of cardiac arrhythmia. Environ Health Perspect. 2014 Jul;122(7):747-53. doi: 10.1289/ehp.1307337. Epub 2014 Mar 25.
PMID: 24667535DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jeremy P Langrish, MB BCh MRCP
University of Edinburgh
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 15, 2008
First Posted
December 17, 2008
Study Start
August 1, 2008
Primary Completion
August 1, 2008
Study Completion
August 1, 2008
Last Updated
December 17, 2008
Record last verified: 2008-12