Aging, Sleep, Cognitive Process

NCT00804804 | Completed

• 1 other identifier: CHUBX 2008/17
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 3

Brief Summary

The aim of the study is to determine the impact of aging, circadian rhythms and sleep deprivation on executive performances. Volunteers will complete a 40-hour extended wakefulness period in constant condition (semi-recumbent posture in bed, constant dim light levels \< 10 lux, food and liquid intake at regular intervals) in order to control the circadian system. The volunteers will not be allowed to sleep in the sleep deprivation protocol ("high sleep pressure protocol") and will adopt a short wakefulness/sleep cycle (150/75 minutes) in the multiple nap protocol ("low sleep pressure protocol"). Tests and scales will be repeated every 3H45

Conditions

BIOLOGICAL CLOCKS

Keywords

Sleep; aging; cognitives processes; constant routine

Outcome Measures

Primary Outcomes (1)

• Executive functions will be evaluated by a Go/NoGo task and a Stop Signal. Performances will be measured with a visual simple reaction time task

  every 3h45

Secondary Outcomes (1)

• Nocturnal sleep quality before and after 2 constant conditions measured by PSG Sleep pressure quantified by Karolinska test and EEG delta band Subjective sleepiness and fatigue evaluated by Karolinska sleepiness scale and visual analogue scale

  every 3h45

Study Arms (4)

Y1

EXPERIMENTAL

young volunteers (20-30 years), morningness chronotype

Other: Sleep deprivation and multiple rest

Y2

EXPERIMENTAL

young volunteers (20-30 years), eveningness chronotype

Other: Sleep deprivation and multiple rest

O1

EXPERIMENTAL

Aged volunteers (65-75 years), morningness chronotype

Other: Sleep deprivation and multiple rest

O 2

EXPERIMENTAL

aged volunteers (65-75 years), eveningness chronotype

Other: Sleep deprivation and multiple rest

Interventions

Sleep deprivation and multiple rest OTHER

To determine the evolution of the executive functions during a 40-hour extended wakefulness period or during a 40-hour multiple nap protocol in constant experimental conditions of confinement

Y1

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• excessive daytime sleepiness (Epworth Sleepiness Scale score \> 9),
• sleep complaint such as sleep apnea or insomnia (Basic Nordic Sleep Questionnaire, items score \< 4 except questions 3, 4 and 15a for aged volunteers),
• not intermediate in terms of morningness and eveningness according to the Horne-Ostberg questionnaire for young volunteers
• absence of psychopathology evidenced during psychologist interview or on the Symptom Check List (SCL-90R score\>59)
• sleep efficiency evidenced by actimetry (\>85%) during 7 days
• absence of apnea/hypopnea syndrome (RDI\<15)
• absence of periodic movement disorder (MPS\<15)
• regular sleep schedule during 3 days before study participation
• affiliated to the french health care system

You may not qualify if:

• volunteers with sleep disorders or organic disorders affecting sleep,
• poor sleep hygiene or abnormal usual sleep patterns,
• night workers or shift-workers,
• substance abusers (caffeine, drug, or alcohol).

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (3)

Genpphass

Bordeaux, 33076, France

Location

Uh Purpan

Toulouse, 31300, France

Location

Medes-Imps

Toulouse, 31405, France

Location

Study Officials

• Pierre PHILIP, MD,PHD

  University Hospital Bordeaux France

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 8, 2008
• First Posted: December 9, 2008
• Study Start: December 1, 2008
• Primary Completion: February 1, 2011
• Study Completion: February 1, 2011
• Last Updated: March 7, 2011

Record last verified: 2011-03

Locations

FR (3)