NCT00800228|Completed
Salt Study: Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure
Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure
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Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure
Sponsor study identifier
observational
96
1 country
1
Study Start
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2006
Actual (reported)Study Completion
December 2006
Actual (reported)The purpose of this study is to test the hypothesis that blood pressure sensitivity to high sodium intake in healthy humans is characterized by increased urinary excretion of two endogenous sodium pump inhibitors, marinobufagenin (MBG), and ouabain-like compound (OLC). The study also tests the hypothesis that women who breathe slowly and have high resting end tidal CO2 at rest are more likely to have low plasma renin activity and sodium sensitivity of blood pressure than those who breathe more rapidly and maintain lower end tidal CO2.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2006
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
December 2006
Actual (reported)December 2006
Actual (reported)November 30, 2008
Actual (reported)December 2, 2008
Actual (reported)The sodium loading procedures will be identical in both experiments, except that 24-hr urine collection will be collected all 12 days in experiment one, but only on the last two days of each sodium diet in experiment two.
Group 1- daily; Group 2 - days 6 & 12
Eight men and eight women to define the time course of changes in MBG \\ and OLC accompanying sodium loading
32 additional women to determine whether breathing pattern is predictive of sodium sensitivity in that gender. Women are being studied in the second experiment because they, but not men, have been shown to have an association of breathing pattern with high perceived stress11 and an association of high resting end tidal CO2 with high resting blood pressure.
Community
NIA Clinical Research Unit
Baltimore, Maryland, 21225, United States
Muntzel M, Drueke T. A comprehensive review of the salt and blood pressure relationship. Am J Hypertens. 1992 Apr;5(4 Pt 1):1S-42S. doi: 10.1093/ajh/5.4s.1s.
Haddy FJ. Digitalislike circulating factor in hypertension: potential messenger between salt balance and intracellular sodium. Cardiovasc Drugs Ther. 1990 Mar;4 Suppl 2:343-9. doi: 10.1007/BF02603174.
Doris PA, Bagrov AY. Endogenous sodium pump inhibitors and blood pressure regulation: an update on recent progress. Proc Soc Exp Biol Med. 1998 Jul;218(3):156-67. doi: 10.3181/00379727-218-44283.
David Anderson, PhD
National Institute on Aging (NIA)
96 participants (actual enrollment reported by the registry).
First Submitted
November 30, 2008
First Posted
December 2, 2008
Study Start
March 2003
Date type not reportedThis date has not been verified as actual or estimated.
Intervention Study to Control High Blood Pressure for Korean American
Contact the study team to confirm eligibility.
Fedorova OV, Anderson DE, Lakatta EG, Bagrov AY. Interaction of NaCl and behavioral stress on endogenous sodium pump ligands in rats. Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R352-8. doi: 10.1152/ajpregu.2001.281.1.R352.
Primary Completion
December 2006
Actual (reported)Study Completion
December 2006
Actual (reported)Last Updated
December 2, 2008
Record last verified: 2008-11
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Source: ClinicalTrials.gov.
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