The Body's Response to Food Intake in Trained, Older Adults

NCT00798668 | Completed

• 2 other identifiers: 0607004184NIH R01 AG021911-0102
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this research study is to determine the effects of food supplements and strength training on appetite, the amount of energy expended, and body composition.

Conditions

Elderly

Keywords

Endocrine and Gastrointestinal Response to Food

Outcome Measures

Primary Outcomes (1)

• Quantify the acute effects of fluid and solid foods on post-prandial (post-meal) appetite and food intake at the next eating occasion in trained and untrained, elderly people.

  6 weeks

Secondary Outcomes (1)

• Quantify the contribution of selected satiety factors (glucose, insulin, CCK, ghrelin, and GLP-1) and gastrointestinal transit time, to the differential appetitive responses to fluid versus solid foods in trained and untrained, elderly people

  6 weeks

Study Arms (4)

1

EXPERIMENTAL

participants continue current exercise and take liquid supplement

Dietary Supplement: Liquid Supplements

2

EXPERIMENTAL

Participants continue current exercise and take solid supplement

Dietary Supplement: Solid Supplement

3

EXPERIMENTAL

Participants continue current sedentary behavior and take liquid supplements

Dietary Supplement: Liquid Supplements

4

EXPERIMENTAL

Participants continue current sedentary behavior and take solid supplements

Dietary Supplement: Solid Supplement

Interventions

Liquid Supplements DIETARY_SUPPLEMENT

Liquid supplement that provides 12.5% of the subjects total energy requirement.

1; 3

Solid Supplement DIETARY_SUPPLEMENT

Solid supplement that provides 12.5% of the subjects total energy requirement.

2; 4

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All subjects must meet the following eligibility criteria:
• Age range: 60 years and older
• Body mass index between 20-29 kg/m2
• Weight stable (\< 2 kg weight change within last 6 months)
• Non-smoking
• Constant habitual activity patterns within last 3 months
• Clinically normal blood profiles (specifically, normal liver and kidney function; normal complete blood count (non-anemic); fasting blood glucose \<110 mg/dl)
• Not taking medications known to influence appetite or metabolism
• Non-diabetic
• Confirmation of acceptability of eating the study test foods (solids and fluids)
• Trained subjects (Recruiting 36; N-25) must meet the following eligibility criteria:
• Resistive exercise training (≥ 2 times a week) based on reported physical activity levels (questionnaire)
• Active fitness level (≥ 2, 30-minute aerobic exercise sessions/week)
• Sedentary subjects (Recruiting 36; N-25) must meet the following eligibility criteria:
• Resistive exercise training (≤ 1 time a week) based on reported physical activity levels (questionnaire)

You may not qualify if:

• Age: \<60 years
• Body mass index: outside of the 20-29 kg/m2 range
• Gained or lost \> 4.5 kg within the last 6 months
• Smoker (currently or within the last year)
• Intermittently been involved in a diet and/or exercise program within the last 3 months
• Clinically abnormal blood profiles as identified by our study physician, Arthur Rosen, MD
• Taking medications (currently or within the last 3 months) known to influence appetite or metabolism
• Clinically diagnosed as diabetic
• Study foods are found to be unacceptable for consumption by the subject
• Clinically diagnosed osteoporosis
• Did not perform resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
• Perform ≤ 1, 30-minute aerobic exercise session/week (currently or within the last 3 months) based on physical activity levels questionnaire)
• Performed resistive exercise training (currently or within the last 3 months) based on reported physical activity levels (questionnaire)
• Perform \> 2, 30-minute aerobic exercise sessions/week (currently or within the last 3 months) based on physical activity levels questionnaire)

Sponsors & Collaborators

• Purdue University: lead

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Foods and Nutrition

Study Record Dates

• First Submitted: November 25, 2008
• First Posted: November 26, 2008
• Study Start: September 1, 2006
• Primary Completion: August 1, 2007
• Study Completion: May 1, 2008
• Last Updated: September 24, 2013

Record last verified: 2010-03

Locations

US (1)