Chemoreflex Sensitivity in Chronic Kidney Disease

NCT00794872 | Completed DMC

• 1 other identifier: Chemoreflex-Sensitivity-Study
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular morbidity and mortality are markedly increased in chronic kidney disease (CKD) and may be explained in part by sympathetic hyperactivity. Impaired hyperoxic chemoreflex sensitivity (CHRS) has been attributed to an increased sympathetic activity. The aim of the present study is to examine whether chemosensor function is altered in patients with stage 3 and stage 4 CKD.

Conditions

Chronic Kidney Disease; Cardiovascular Morbidity

Keywords

Cardiovascular autonomic neuropathy; Chemoreflex sensitivity; Chronic kidney disease; Sudden cardiac arrest

Outcome Measures

Primary Outcomes (1)

• Hyperoxic chemoreflex sensitivity is impaired in patients with moderate to severe chronic kidney disease

Study Arms (3)

1

Patients with stage 3 CKD

Other: blood sampling

2

Patients with stage 4 CKD

Other: blood sampling

3

Patients without evidence for CDK

Other: blood sampling

Interventions

blood sampling OTHER

1; 2; 3

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients suffering from CDK stage 3 (GFR 30-59 ml/min/1.73 m²) or stage 4 (GFR 15-29 ml/min/1.73 m²)
• For the reference Patients without evidence for CDK

You may not qualify if:

• Patients with heart failure, history of myocardial infarction or instable angina pectoris, atrial fibrillation, hyperthyroidism, chronic pulmonary diseases, sleep apnoea syndrome, alcohol abuse and drug induced cardiomyopathy

Sponsors & Collaborators

• RWTH Aachen University: lead
• Heinrich-Heine University, Duesseldorf: collaborator
• SLK Kliniken Heilbronn GmbH: collaborator

Study Sites (1)

Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine

Aachen, North Rhine-Westphalia, 52074, Germany

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Measurement of the venous partial pressure of oxygen in blood samples

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Death, Sudden, Cardiac

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Arrest; Heart Diseases; Cardiovascular Diseases; Death, Sudden; Death

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Christian Meyer, MD

  RWTH Aachen University Departement of Cardiology, Pulmonology and Vascular Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 19, 2008
• First Posted: November 20, 2008
• Study Start: January 1, 2007
• Primary Completion: November 1, 2008
• Study Completion: November 1, 2008
• Last Updated: November 20, 2008

Record last verified: 2008-11

Locations

DE (1)