Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams
The Comparative Results of Penicillin Testing in Patients With History of Allergic Reactions to Betalactams Between Using In-house Penicillin Test Preparation and Commercial Available Penicillin Testing Kit
1 other identifier
interventional
63
1 country
1
Brief Summary
This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Dec 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 7, 2008
CompletedFirst Posted
Study publicly available on registry
November 11, 2008
CompletedStudy Start
First participant enrolled
December 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2010
CompletedNovember 29, 2010
November 1, 2010
1.2 years
November 7, 2008
November 26, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The skin testing results of in-house penicillin skin test and Penicillin G Sodium compared to commercial penicillin testing kit
1 year
Secondary Outcomes (2)
Clinical correlation and side effects
1 year
Correlations between Penicillin skin test result with specific IgE and/or basophil activation test
1 year
Study Arms (3)
In-house penicillin testing preparation
ACTIVE COMPARATORIn-house penicillin testing prepared from alkali-treated penicillin G
Commercial penicillin test kit
ACTIVE COMPARATORCommercial penicillin test kit order from Diater company
Penicillin G Sodium
ACTIVE COMPARATORPenicillin G Sodium from routine clinical use
Interventions
Intradermal test with immediate reading
Eligibility Criteria
You may qualify if:
- Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins
- years of age
You may not qualify if:
- On antihistamine/ cannot discontinue antihistamine before the test
- Having asthma exacerbation
- Being pregnant
- Suffering from severe systemic disease/ in bad health
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Chulalongkorn Universitylead
- Mahidol Universitycollaborator
Study Sites (1)
Faculty of Medicine, Chulalongkorn University
Bangkok, 10330, Thailand
Related Publications (1)
Wangrattanasopon P, Ruxrungtham K, Chantaphakul H, Buranapraditkun S, Klaewsongkram J. Alkali-treated penicillin G solution is a better option than penicillin G as an alternative source of minor determinants for penicillin skin test. Allergy Asthma Proc. 2012 Mar-Apr;33(2):152-9. doi: 10.2500/aap.2012.33.3496.
PMID: 22525392DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jettanong Klaewsongkram, MD
Chulalongkorn University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
November 7, 2008
First Posted
November 11, 2008
Study Start
December 1, 2008
Primary Completion
March 1, 2010
Study Completion
August 1, 2010
Last Updated
November 29, 2010
Record last verified: 2010-11