A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

NCT00784264 | Completed

• 1 other identifier: NIS-CHK-DUM-2008/1
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

Conditions

Atherosclerosis

Keywords

Asymptomatic atherosclerosis; Intima media thickness (IMT); central obesity; cardiovascular disease

Outcome Measures

Primary Outcomes (1)

• To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong,

  during the one single study visit

Secondary Outcomes (2)

• To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong.

  During the one single study visit

• IMT results to be compared with what being reported in the recent literature on normal Chinese population.

  During the one single study visit

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

aged 55 or above with central obesity, male more than 90 cm; female more than 80 cm

You may qualify if:

• Male or female aged 55 years or above.
• Waist circumference: male more than 90 cm; female more than 80 cm.

You may not qualify if:

• Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia.
• Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease.
• Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Sponsors & Collaborators

• AstraZeneca: lead

Study Sites (1)

Research Site

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Atherosclerosis; Obesity, Abdominal; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Karen Yuen

  AstraZeneca Hong Kong Ltd

  STUDY DIRECTOR

• Chun chung Chow, MD

  Prince of Wales Hospital, Shatin, Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY

Study Record Dates

• First Submitted: October 22, 2008
• First Posted: November 3, 2008
• Study Start: October 1, 2008
• Study Completion: June 1, 2009
• Last Updated: January 12, 2010

Record last verified: 2010-01

Locations

HK (1)