NCT00780221|UnknownDMC
C-Reactive Protein (CRP) Gene Variants and Coronary Artery Disease in a Chinese Han Population
CRP-Han
CRP Gene Variants and Coronary Artery Disease in a Chinese Han Population
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CRP-Han
CRP Gene Variants and Coronary Artery Disease in a Chinese Han Population
Sponsor study identifier
Secondary identifiers
observational
1,000
1 country
1
Study Start
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on CRP level and CHD. However, the causality of CRP variants remains uncertain.The objective of this study is to evaluate the association of CRP gene variants and CRP levels in CHD in Chinese Han population. We conduct case-control study in CRP-Han study participants. The common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels are detected. A Mendelian randomization analysis will be used to help test the likelihood of causal association of gene-CRP levels, CRP levels-CHD and gene-CHD. The investigators hypothesize that CRP gene variants influence the protein level and may participate in CHD progress.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
October 24, 2008
Actual (reported)October 27, 2008
Actual (reported)October 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
patients without coronary artery disease
patients with coronary artery disease
in-hospital patients and community healthy individual
Zhongshan Hospital
Shanghai, Shanghai Municipality, 200032, China
Blood sample will be examined and DNA variants be analyzed.
Junbo Ge
Shanghai Zhongshan Hospital
First Submitted
October 24, 2008
First Posted
October 27, 2008
Study Start
October 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2010
Estimated (date passed)Safety and Efficacy Registry of Yinyi Stent
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2010
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
October 27, 2008
Record last verified: 2008-10
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