NCT00779064

Brief Summary

This is a clinical study investigating pharmacokinetics, pharmacodynamic effects and safety of BAY 59-7939 in patients with atrial fibrillation (originally described in Japanese).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
36

participants targeted

Target at below P25 for phase_2 atrial-fibrillation

Timeline
Completed

Started Jul 2004

Shorter than P25 for phase_2 atrial-fibrillation

Geographic Reach
1 country

12 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2004

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2005

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2005

Completed
3.4 years until next milestone

First Submitted

Initial submission to the registry

October 17, 2008

Completed
7 days until next milestone

First Posted

Study publicly available on registry

October 24, 2008

Completed
Last Updated

December 25, 2014

Status Verified

December 1, 2014

Enrollment Period

11 months

First QC Date

October 17, 2008

Last Update Submit

December 23, 2014

Conditions

Keywords

Atrial Fibrillation

Outcome Measures

Primary Outcomes (1)

  • Pharmacokinetics (PK) CL/f, AUC, Cmax, Pharmacodynamics (PD), Factor Xa activity, PT, PT-INR, aPTT and HEPTEST(R)

    Day 14 and 28

Secondary Outcomes (1)

  • Each category of bleeding events and adverse event

    Throughout treatment and followup period

Study Arms (2)

Arm 1

EXPERIMENTAL
Drug: Rivaroxaban (BAY59-7939)

Arm 2

EXPERIMENTAL
Drug: Rivaroxaban (BAY59-7939)

Interventions

10mg BID, Semi-sequential, dose escalation.

Arm 1

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years or older
  • Japanese male or female
  • Non- valvular atrial fibrillation documented by ECG
  • Patients aged 60 years and older or with a risk of stroke

You may not qualify if:

  • Prior stroke and TIA
  • Patients in whom anticoagulants are contraindicated

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (12)

Unknown Facility

Fukuoka, Fukuoka, 811-0213, Japan

Location

Unknown Facility

Fukuoka, Fukuoka, 814-0180, Japan

Location

Unknown Facility

Kitakyushu, Fukuoka, 800-0057, Japan

Location

Unknown Facility

Koga, Fukuoka, 807-0051, Japan

Location

Unknown Facility

Kurume, Fukuoka, 830-8577, Japan

Location

Unknown Facility

Kitahiroshima, Hokkaido, 061-1134, Japan

Location

Unknown Facility

Amagasaki, Hyōgo, 660-8511, Japan

Location

Unknown Facility

Kawachi-Nagano, Osaka, 586-8521, Japan

Location

Unknown Facility

Osaka, Osaka, 540-0006, Japan

Location

Unknown Facility

Osaka, Osaka, 553-0003, Japan

Location

Unknown Facility

Osaka, Osaka, 558-8558, Japan

Location

Unknown Facility

Suita, Osaka, 565-0871, Japan

Location

MeSH Terms

Conditions

Atrial Fibrillation

Interventions

Rivaroxaban

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

ThiophenesSulfur CompoundsOrganic ChemicalsMorpholinesOxazinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Officials

  • Bayer Study Director

    Bayer

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 17, 2008

First Posted

October 24, 2008

Study Start

July 1, 2004

Primary Completion

June 1, 2005

Study Completion

June 1, 2005

Last Updated

December 25, 2014

Record last verified: 2014-12

Locations