The Effect of Remote Preconditioning on the Exercise Performance of the Elite Swimmers

NCT00761566 | Completed Phase 2

• 1 other identifier: 1000012617
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we will test the hypothesis that preconditioning highly trained swimmers using skeletal muscle ischemia as the stimulus will improve exercise performance assessment.

Conditions

Healthy

Keywords

Elite swimmers; Exercise; Preconditioning

Outcome Measures

Primary Outcomes (1)

• Improvement in the peak velocity in the preconditioning subjects.

  2 weeks

Secondary Outcomes (3)

• Breathing frequency.

  2 weeks

• Blood lactate.

  2 weeks

• Improvement in critical speed.

  2 weeks

Study Arms (2)

1

EXPERIMENTAL

Other: Real preconditioning followed by Sham preconditioning

2

EXPERIMENTAL

Other: Sham preconditioning followed by Real preconditioning

Interventions

Real preconditioning followed by Sham preconditioning OTHER

Subjects in this arm of the study will first receive four 5 minute cycles of upper limb ischemia interspaced with 5 minutes of reperfusion by using a blood-pressure cuff inflated to a pressure of 15 mmHg greater than systolic arterial pressure. The subjects will then cross-over to the other arm of the study and receive four 5 minute cycles of upper limb ischemia interspaced with 5 minutes of reperfusion by using a sham procedure consisting of inflating the blood pressure cuff to 10 mmHg.

1

Sham preconditioning followed by Real preconditioning OTHER

Subjects in this arm of the study will first receive four 5 minute cycles of upper limb ischemia interspaced with 5 minutes of reperfusion by using a sham procedure consisting of inflating the blood pressure cuff to 10 mmHg. They will then cross-over to the other arm of the study and receive four 5 minute cycles of upper limb ischemia interspaced with 5 minutes of reperfusion by using a blood-pressure cuff inflated to a pressure of 15 mmHg greater than systolic arterial pressure.

2

Eligibility Criteria

• Age: 13 Years - 22 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Healthy male or female athlete volunteers
• Post-pubescent swimmers between the ages of 13 and 22 years (or healthy non-athletes (for the "equipment control" group and for the control arm for the animal model section)
• Members of competitive swimming teams
• Have achieved a swimming performance time within 5% of national qualification standards

You may not qualify if:

• Illness, surgery, or medical intervention within the last 48 hours
• Diabetes mellitus

Sponsors & Collaborators

• The Hospital for Sick Children: lead

Study Sites (1)

Toronto Swim Club, University of Toronto Athletic Centre

Toronto, Ontario, Canada

Location

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Andrew Redington, MD

  The Hospital for Sick Children

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head, Heart Centre-Cardiology Division

Study Record Dates

• First Submitted: September 26, 2008
• First Posted: September 29, 2008
• Study Start: October 1, 2008
• Primary Completion: February 1, 2010
• Study Completion: February 1, 2010
• Last Updated: August 15, 2013

Record last verified: 2013-08

Locations

CA (1)