Change of Neutrophil Gelatinase-Associated Lipocalin(NGAL) Following Sodium Phosphate Bowel Preparation(Pilot Study)

NCT00760591 | Unknown

• 1 other identifier: 2008-41
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Oral phosphate purgative is the preferred bowel regimen on the basis of better tolerability, cost effectiveness, and efficacy. There are also numerous reports of patients with even previously normal renal function developing acute and chronic kidney disease after use of oral phosphate purgative. Several uncontrolled case reports and case series suggest a potential link between oral phosphate and acute kidney injury and/or chronic kidney disease1. Its use is contraindicated in patients with preexisting renal disease because of the risk for developing acute renal failure, so called acute phosphate nephropathy, or electrolyte disturbance. Since most of the outpatients who are going to undergo a colonoscopy are exposed to this agent, it is important to detect or prevent vulnerable patients. We would seek a sensitive and rapid diagnosis method of acute kidney injury following sodium phosphate bowel preparation. Within a few hours, NGAL mRNA is highly upregulated after kidney injury, such as renal ischemia-reperfusion and cisplatin nephropathy, NGAL induction precedes the elevation of classical markers for kidney damage such as serum creatinine. The investigators will investigate the change of NGAL following sodium phosphate bowel preparation.

Conditions

Acute Kidney Failure

Keywords

Acute kidney failure; Colonoscopy; Neutrophil gelatinase-associated lipocalin

Outcome Measures

Primary Outcomes (1)

• NGAL

  Baseline, colonoscopy day, post 1day, post 2 day

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

18-65 year old volunteers who want to get colonoscopy

You may not qualify if:

• Who takes ACE-inhibitor, ARB
• Has a renal or heart disease
• Has a serum electrolyte disturbance

Sponsors & Collaborators

• Soon Chun Hyang University: lead

Study Sites (1)

Soon Chun Hyang University Hospital

Seoul, 140-743, South Korea

RECRUITING

Biospecimen

Retention: NONE RETAINED

Serum, Urine

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Soon Hyo Kwon, MD

CONTACT

+8-02-709-9491; ksoonhyo@hosp.sch.ac.kr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 25, 2008
• First Posted: September 26, 2008
• Study Start: September 1, 2008
• Last Updated: September 26, 2008

Record last verified: 2008-09

Locations

KR (1)