Effect of Early Pulmonary Rehabilitation After Lung Transplantation

NCT00759538 | Completed

• 1 other identifier: MHH-2008-4
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this observation study is to evaluate the effects of an early, 3 week lasting rehabilitation program, that starts roundabout 4 weeks after lung or combined lung transplantation, on physical activity, functional and physical condition (6-min-walk, FEV1, ADL-score) and quality of life (SF36) in lung transplant recipients with a different length of stay on the waiting list and a different duration of hospitalization in the transplantation centre after transplantation.

Conditions

Lung Transplantation

Keywords

Lung Transplantation; Pulmonary Rehabilitation; Exercise tolerance; Quality of Life

Outcome Measures

Primary Outcomes (1)

• Exercise capacity at the end of an early short-term after lung transplantation

  3 years

Secondary Outcomes (4)

• Lung function

  3 years

• Body composition

  3 years

• Activities of daily living

  3 years

• Health Status (SF-36)

  3 years

Study Arms (1)

1

lung transplant patients performing a three week lasting rehabilitation program

Eligibility Criteria

• Age: 17 Years - 67 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

lung transplant patients performing a three week lasting rehabilitation program

You may qualify if:

• Recipients of single or double lung transplants
• Recipients of combined (heart and lung or heart an liver) transplants

Sponsors & Collaborators

• Hannover Medical School: lead
• Klinik Fallingbostel Rehabilitation Center: collaborator

Study Sites (1)

Hannover Medical School, Dpt. of Respiratory Medicine

Hanover, Germany

Location

Related Publications (5)

• Tegtbur U, Sievers C, Busse MW, Pethig K, Warnecke G, Kugler C, Gutzlaff E, Kunsebeck HW, Struber M, Haverich A, Niedermeyer J. [Quality of life and exercise capacity in lung transplant recipients]. Pneumologie. 2004 Feb;58(2):72-8. doi: 10.1055/s-2003-812526. German.

  PMID: 14961434 BACKGROUND

• Schwaiblmair M, Reichenspurner H, Muller C, Briegel J, Furst H, Groh J, Reichart B, Vogelmeier C. Cardiopulmonary exercise testing before and after lung and heart-lung transplantation. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1277-83. doi: 10.1164/ajrccm.159.4.9805113.

  PMID: 10194177 BACKGROUND

• Schultz K, Bergmann KC, Kenn K, Petro W, Heitmann RH, Fischer R, Lang SM. [Effectiveness of inpatient pulmonary rehabilitation (AHB). Results of a multicenter prospective observation study]. Dtsch Med Wochenschr. 2006 Aug 18;131(33):1793-8. doi: 10.1055/s-2006-949155. German.

  PMID: 16902901 BACKGROUND

• Maury G, Langer D, Verleden G, Dupont L, Gosselink R, Decramer M, Troosters T. Skeletal muscle force and functional exercise tolerance before and after lung transplantation: a cohort study. Am J Transplant. 2008 Jun;8(6):1275-81. doi: 10.1111/j.1600-6143.2008.02209.x. Epub 2008 Apr 29.

  PMID: 18444941 BACKGROUND

• Dierich M, Tecklenburg A, Fuehner T, Tegtbur U, Welte T, Haverich A, Warnecke G, Gottlieb J. The influence of clinical course after lung transplantation on rehabilitation success. Transpl Int. 2013 Mar;26(3):322-30. doi: 10.1111/tri.12048. Epub 2013 Jan 7.

  PMID: 23294442 DERIVED

Study Officials

• Martin Dierich, MD

  Hannover Medical School, Dpt. of Respiratory Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: September 24, 2008
• First Posted: September 25, 2008
• Study Start: July 1, 2007
• Primary Completion: July 1, 2007
• Study Completion: December 1, 2008
• Last Updated: July 31, 2012

Record last verified: 2012-07

Locations

DE (1)