Coronary Artery Bypass Grafting: Factors Related to Late Events and Saphenous Graft Patency
1 other identifier
observational
300
1 country
1
Brief Summary
The purpose of this study is to determine the relations between conventional and unconventional risk factors and adverse clinical events at follow-up (including coronary bypass patency) in patients undergoing surgical myocardial revascularization.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2007
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2007
CompletedFirst Submitted
Initial submission to the registry
September 16, 2008
CompletedFirst Posted
Study publicly available on registry
September 18, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2011
CompletedSeptember 18, 2008
September 1, 2008
September 16, 2008
September 16, 2008
Conditions
Keywords
Study Arms (1)
1
Pts undergoing CABG or OPCAB
Interventions
Eligibility Criteria
You may qualify if:
- Men and women age 18 to 89
- Elective primary CABG
- Female patients must be non-lactating and not pregnant
- Able and willing to comply with study requirements by signing a consent form
You may not qualify if:
- Concomitant surgery
- Major end organ dysfunction
- Serious intercurrent illness or infection
- Known coagulation disorders
- Emergencies
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centro Cardiologico Monzino
Milan, Milan, 20138, Italy
Related Publications (1)
1. American Heart Association. Heart disease and stroke statistics - 2005 update. Dallas, TX: AHA 2004 2. Lytle BW. Prolonging patency - choosing coronary bypass grafts. N Engl J Med 2004; 351: 2262-4 3. Motwani JG et al. Aortocoronary saphenous vein graft disease : pathogenesis, predisposition and prevention. Circulation 1998; 97:916-31 4. Yilmaz M et al. Metabolic syndrome negatively impacts early patency of saphenous vein grafts. Coronary artery disease 2006; 17:41-4 5. Moor E et al. Haemostatic function in patients undergoing coronary artery bypass grafting: perioperative perturbations and relations to saphenous vein graft closure. Thrombosis research 2000; 98:39-49 6. Podgoreanu M et al. New paradigms in cardiovascular medicine. JACC 2005; 46:1965-77 7. Stafford-Smith M et al. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dusease 2005; 45:519-30 8. Moor E et al. Coagulation factor V (Arg506à Gln) mutation and early saphenous graft occlusion after coronary artery bypass grafting. Thromb Haemost 1998; 80:220-4 9. Yende S et al. Clinical relevance of ACE gene polymorphisms topredict risk of mechanical ventilation after coronary artery bypass surgery. Crit Care Med 2004; 32: 922-27
BACKGROUND
Biospecimen
Plasma,serum, whole blood
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Alessandro Parolari, MD, PhD
Centro Cardiologico Monzino - Milano
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
September 16, 2008
First Posted
September 18, 2008
Study Start
January 1, 2007
Study Completion
January 1, 2011
Last Updated
September 18, 2008
Record last verified: 2008-09