Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth

NCT00750828 | Completed DMC

• 1 other identifier: Hacettepe # FON 03/6-14
• Study Type: observational
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators questioned whether patients with dry mouth complaints display any reduction in residual saliva coating the gingiva and other selected mucosal surfaces. We further intended to test the hypothesis that Gingival Crevicular Fluid volume in patients with dry mouth could be different from that of control subjects. Correlations between gingival/mucosal wetness; and unstimulated whole salivary flow rate or minor salivary gland secretion rates and the correlations between clinical periodontal status and salivary measures were also attempted.

Conditions

Xerostomia; Sjogren's Syndrome

Keywords

Saliva; Sjögren's Syndrome; GCF; Oral Mucosal Wetness

Eligibility Criteria

• Age: 46 Years - 56 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The data for this study were taken from 28 subjects at the Department of Periodontology, Hacettepe University from 2004 to 2007. The study group consisted of 14 patients with dry mouth complaints. All of them had the diagnosis of Sjögren's syndrome and ten of them were on therapy for sicca symptoms. Fourteen randomly selected age-matched systemically healthy females were also included as a control group

You may qualify if:

• For test group dry mouth complaints and with a diagnosis ofSjogren's Syndrome

You may not qualify if:

• Other medical problems that effect salivary glands

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Department of Periodontology, Faculty of Dentistry, Hacettepe University,

Ankara, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Xerostomia; Sjogren's Syndrome

Condition Hierarchy (Ancestors)

Salivary Gland Diseases; Mouth Diseases; Stomatognathic Diseases; Arthritis, Rheumatoid; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Dry Eye Syndromes; Lacrimal Apparatus Diseases; Eye Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Burak Demiralp, DDS PhD

  Hacettepe University Faculty of Dentistry Department of Periodontology

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 10, 2008
• First Posted: September 11, 2008
• Study Start: January 1, 2004
• Primary Completion: December 1, 2007
• Study Completion: March 1, 2008
• Last Updated: September 11, 2008

Record last verified: 2008-09

Locations

TU (1)