Evaluation of Toxic Metals, Trace Elements and Total Antioxidant Activity in Children With Recurrent Wheezing

NCT00749528 | Completed

• 1 other identifier: 2008-08-11
• Study Type: observational
• Target: 95
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate hair trace elements and toxic metals and plasma total antioxidant activity in children with recurrent wheezing and to evaluate whether these toxic metals and trace elements have any impact on serum cytokine levels.

Conditions

Asthma; Wheezing

Keywords

Wheezing; Hair trace elements; Hair toxic metals; Oxidative stress

Outcome Measures

Primary Outcomes (1)

• Hair toxic metal and trace element status in the two groups

  6 months

Secondary Outcomes (2)

• To compare plasma total antioxidant activity in the two groups.

  6 months

• Effect of heavy metals and trace elements on plasma cytokine levels and difference between the two groups

  6 months

Study Arms (2)

1

Children vith recurrent wheezing

2

Healthy children

Eligibility Criteria

• Age: 6 Months - 6 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Group 1: Children with recurrent wheezing Group 2: Age and sex matched healthy children

You may qualify if:

• Children with recurrent wheezing ages between 6 months to 6 years old.
• Age and sex matched healthy children for control group.
• Parental/guardian permission (informed consent)

You may not qualify if:

• Systemic corticosteroid use in the last 30 days
• Chronic lung diseases including cystic fibrosis
• Immunodeficiency
• Known renal or hepatic dysfunction
• Respiratory truck infections in the last 30 days
• Anatomic abnormalities of the respiratory tract
• Suspected foreign body aspiration or croup
• Immunosuppressive or immunostimulant treatment

Sponsors & Collaborators

• Kecioren Education and Training Hospital: lead

Study Sites (1)

Kecioren Eğitim Araştırma Hastanesi

Ankara, Kecioren, 06380, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Group 1: Children with recurrent wheezing. Plasma and Hair specimen are retined Group 2: Healthy children. Plasma and Hair specimen are retined

MeSH Terms

Conditions

Asthma; Respiratory Sounds

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• C H RAZI, MD

  Kecioren Education and Training Hospital

  STUDY DIRECTOR

• C H RAZI, MD

  Kecioren Education and Training Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Kecioren Education and Training Hospital

Study Record Dates

• First Submitted: September 8, 2008
• First Posted: September 9, 2008
• Study Start: September 1, 2007
• Primary Completion: July 1, 2008
• Study Completion: July 1, 2008
• Last Updated: March 15, 2012

Record last verified: 2008-08

Locations

TU (1)