Using Ultrasound to Predict Response to Intraarticular Corticosteroids in Knee Osteoarthritis
1 other identifier
interventional
79
1 country
2
Brief Summary
A study using characteristics on ultrasound to predict response to intraarticular steroid injections in patients with knee osteoarthritis. The hypothesis is that patients with inflammation on ultrasound will have a better response to corticosteroid injections compared to patients without inflammation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2004
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2008
CompletedFirst Submitted
Initial submission to the registry
September 3, 2008
CompletedFirst Posted
Study publicly available on registry
September 4, 2008
CompletedResults Posted
Study results publicly available
August 25, 2010
CompletedAugust 25, 2010
September 1, 2008
4.3 years
September 3, 2008
April 5, 2010
July 29, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Western Ontario and McMasters Universities Arthritis Index (WOMAC) Pain Subscale
WOMAC pain subscale range 0-20 (0=best, 20=worst)
baseline to 4 weeks
Other Outcomes (1)
Change in WOMAC Pain Subscale
baseline to 12 weeks
Study Arms (2)
Corticosteroid Injection
ACTIVE COMPARATOR40 mg of intraarticular triamcinolone acetonide
Placebo Injection
PLACEBO COMPARATORIntraarticular injection of 0.9% saline
Interventions
single intraarticular injection of 40 mg of triamcinolone acetonide
Eligibility Criteria
You may qualify if:
- knee pain
- diagnosis of osteoarthritis in affected knee
You may not qualify if:
- intraarticular corticosteroids in affected knee within past three months
- primary inflammatory connective tissue disease (ie rheumatoid arthritis)
- currently taking oral corticosteroids
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of California San Diego Medical Center
La Jolla, California, 92093, United States
San Diego VA Hospital
La Jolla, California, 92161, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Jeannie Chao
- Organization
- UCSD
Study Officials
- PRINCIPAL INVESTIGATOR
Kenneth Kalunian, MD
University of California, San Diego
- STUDY CHAIR
Anna Quan, MD
San Diego VA Hospital
- STUDY DIRECTOR
Michal Kalli Hose, MD
San Diego VA Hospital
- STUDY DIRECTOR
Jeannie Chao, MD
University of California, San Diego
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
September 3, 2008
First Posted
September 4, 2008
Study Start
March 1, 2004
Primary Completion
July 1, 2008
Study Completion
September 1, 2008
Last Updated
August 25, 2010
Results First Posted
August 25, 2010
Record last verified: 2008-09