Sponsor study identifier
interventional
96
1 country
1
Study Start
January 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
October 2014
Actual (reported)Study Completion
October 2014
Actual (reported)Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence. The objective of this study is to evaluate the efficacy of prazosin (16mg) versus placebo in reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD and PTSD.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2014
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 28, 2008
Actual (reported)August 29, 2008
Actual (reported)January 2009
Date type not reportedThis date has not been verified as actual or estimated.
October 2014
Actual (reported)October 2014
Actual (reported)January 18, 2016
Actual (reported)Number of Drinking Days
Using the Timeline Follow Back method, a calendar method for assessing drug and alcohol use
12 weeks
Clinician-Administered PTSD Scale
Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). A higher score is associated with higher severity of PTSD. The score is interpreted as follows: 0-19=Asymptomatic/few symptoms 20-39=Sub-threshold/mild PTSD 40-59=Threshold PTSD/moderate 60-79=Severe PTSD \>80=Extreme PTSD
12 weeks
prazosin (16mg/day)
Placebo in identical looking capsule blister packs
prazosin (16mg/day) 2 times a day
Placebo
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
VA Connecticut Healthcare System
West Haven, Connecticut, 06516, United States
Gandelman E, Petrakis I, Kachadourian L, Ralevski E. Negative Affect Intensity and Hostility in Individuals With Alcohol Use Disorder With or Without Posttraumatic Stress Disorder. J Dual Diagn. 2018 Apr-Jun;14(2):96-101. doi: 10.1080/15504263.2018.1434264. Epub 2018 Apr 25.
Ismene Petrakis, MD
Yale University
96 participants (actual enrollment reported by the registry).
First Submitted
August 28, 2008
First Posted
August 29, 2008
Study Start
January 2009
Date type not reportedThis date has not been verified as actual or estimated.
Prazosin Alcohol Dependence IVR Study
Contact the study team to confirm eligibility.
Primary Completion
October 2014
Actual (reported)Study Completion
October 2014
Actual (reported)Last Updated
March 19, 2020
Results First Posted
January 18, 2016
Record last verified: 2020-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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