NCT00743132

Brief Summary

ARF is a frequent event after hepatic resection and therefore clinically highly relevant. There is limited evidence on the incidence of postoperative ARF and its clinical relevance in patients undergoing liver resection. This study will evaluate the incidence of acute renal failure (ARF) after liver resection and its impact on postoperative mortality.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
569

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2008

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

August 27, 2008

Completed
1 day until next milestone

First Posted

Study publicly available on registry

August 28, 2008

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2008

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2008

Completed
Last Updated

January 25, 2010

Status Verified

January 1, 2010

Enrollment Period

6 months

First QC Date

August 27, 2008

Last Update Submit

January 22, 2010

Conditions

Acute Renal Failure

Keywords

evaluationincidenceliver surgeryresectionimpactpostoperativemortality

Outcome Measures

Primary Outcomes (2)

  • Predictor score

  • Incidence of ARF Length of hospital stay

Study Arms (2)

1

Postoperative no renal dysfunction

2

Postoperative renal dysfunction

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with benign and malign liver diseases of the Swiss HPB (Hepato-Pancreato-Biliary) Center undergoing liver resection from 2002 - 2007

You may qualify if:

  • Patient age \>/= 18 years
  • Benign and malign liver diseases

You may not qualify if:

  • Trauma cases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Swiss HPB (Hepato-Pancreato-Biliary) Center of the University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland

Location

Related Publications (1)

  • Slankamenac K, Breitenstein S, Held U, Beck-Schimmer B, Puhan MA, Clavien PA. Development and validation of a prediction score for postoperative acute renal failure following liver resection. Ann Surg. 2009 Nov;250(5):720-8. doi: 10.1097/SLA.0b013e3181bdd840.

    PMID: 19809295DERIVED

MeSH Terms

Conditions

Acute Kidney InjuryTooth, Impacted

Condition Hierarchy (Ancestors)

Renal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesTooth DiseasesStomatognathic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

August 27, 2008

First Posted

August 28, 2008

Study Start

April 1, 2008

Primary Completion

October 1, 2008

Study Completion

December 1, 2008

Last Updated

January 25, 2010

Record last verified: 2010-01

Locations

CH(1)