Effect of Osteopathic Lymphatic Treatment on Plasma Volume, Protein Concentration and Albumin Concentration.
The Short-Term Effect of Osteopathic Lymphatic Treatment on Blood Cell Count, Plasma Protein, and Blood Pressure: A Pilot Study in a Cross-Over Design
1 other identifier
interventional
15
1 country
1
Brief Summary
The goal of this project is to see how much an osteopathic lymphatic treatment (OLT) causes an increase in plasma volume, total plasma protein concentration, and albumin concentration. This is an important step in understanding the effects of OLT, specifically its effects on fluid in the body. The primary role of the lymph system is the return of fluid and proteins lost from the blood vessels. Despite this, no research has been done to see what effects an OLT has on fluid and protein levels in the blood.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable healthy-volunteers
Started May 2005
Typical duration for not_applicable healthy-volunteers
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2006
CompletedFirst Submitted
Initial submission to the registry
August 26, 2008
CompletedFirst Posted
Study publicly available on registry
August 28, 2008
CompletedAugust 28, 2008
August 1, 2008
2 months
August 26, 2008
August 27, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Baseline blood pressure
15 minute
Secondary Outcomes (1)
Plasma proteins
15 minute
Study Arms (2)
A
EXPERIMENTALOLT administration
B
SHAM COMPARATORplacebo-OLT
Interventions
direct myofascial release for the thoracic inlet for 30 seconds, supine rib raising for 1 minute on each side of the body, thoracic pumping for one minute, thoracic vacuum for 30 seconds, doming of the abdominal diaphragm for 30 seconds, abdominal pumping for 1 minute, pedal pumping for 1 minute, a second thoracic pump for 1 minute, a second thoracic vacuum for 30 seconds, and a final direct myofascial release for the thoracic inlet lasting 30 seconds
Eligibility Criteria
You may qualify if:
- Normal, healthy volunteers
- Males
- Age 20 to 40 years
You may not qualify if:
- History of cardiovascular, kidney, or liver disease.
- Cannot have taken medication or drugs or have been ill at the time of the study or for two weeks prior.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Dybedal Clinical Research Center, Kansas City University of Medicine and Biosciences
Kansas City, Missouri, 64106, United States
Related Publications (1)
Rivers WE, Treffer KD, Glaros AG, Williams CL. Short-term hematologic and hemodynamic effects of osteopathic lymphatic techniques: a pilot crossover trial. J Am Osteopath Assoc. 2008 Nov;108(11):646-51.
PMID: 19011227DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
W. Evan Rivers, DO
Kansas City University of Medicine and Biosciences
- STUDY DIRECTOR
Charlott L. Williiams, RN, CCRC
Kansas City University of Medicine and Biosciences
- STUDY DIRECTOR
Alan G. Glaros, PhD
KCUMB
- STUDY CHAIR
Kevin Treffer, DO
KCUMB
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 26, 2008
First Posted
August 28, 2008
Study Start
May 1, 2005
Primary Completion
July 1, 2005
Study Completion
July 1, 2006
Last Updated
August 28, 2008
Record last verified: 2008-08