Assessment of Cardiac Involvement of Common Cold in High Performing Athletes by Cardiac Magnetic Resonance Imaging (MRI)

NCT00739895 | Terminated DMC

• 1 other identifier: Athletes_001
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular magnetic resonance (CMR) imaging will be used to assess the impact of common colds and physical training in high-performing athletes. Healthy individuals from the general public will serve as a comparison group. CMR has previously been shown to accurately assess cardiac function, edema, inflammation, and injury. Athletes competing at National level and Developmental Canadian teams will be prospectively recruited. All participants will have CMR scans at low and high intensity training. Participants will be re-scanned immediately after clinical evidence of a common cold, as determined by respiratory and flu-like symptoms. After 4 weeks, a follow-up CMR scan will be performed. On the day of each CMR scan, electrocardiograms and blood samples will be drawn from each participant. Blood samples will provide markers of systemic inflammation, such as leukocyte counts. At each CMR scan, athletes will be asked to describe there recent history of physical exertion in questionnaires, which will reflect the degree of physical exertion performed.

Conditions

Ventricular Function, Left

Keywords

athletes

Outcome Measures

Primary Outcomes (1)

• Left-ventricular systolic dysfunction, as defined by increased left ventricular end-diastolic volume

  12 months

Secondary Outcomes (1)

• Myocardial edema, fibrosis, inflammation, volumetry

  12 months

Study Arms (1)

Athletes

high performing athletes

Procedure: Cardiac magnetic Resonance study; Procedure: Blood testing

Interventions

Cardiac magnetic Resonance study PROCEDURE

follow-up studies

Athletes

Blood testing PROCEDURE

Blood sample tested for myocardial biomarkers

Athletes

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

high performance athletes, during acute viremia and at variable training intensities. Healthy individuals from the general public will serve as a reference group.

You may qualify if:

• Informed consent;
• feverish feeling with last 72 hours;
• active participation in competitive sports;
• history of recent viral exposure or flu-like symptoms.

You may not qualify if:

• CMR Contraindications,
• chronic diseases affecting the heart,
• use of immuno-active drugs

Sponsors & Collaborators

• University of Calgary: lead

Study Sites (1)

Stephenson CMR Centre at Foothills Medical Centre, University of Calgary

Calgary, Alberta, T2N 2T9, Canada

Location

MeSH Terms

Interventions

Hematologic Tests

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Matthias G Friedrich, MD, FESC

  University of Calgary

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: adunct Research Associate Professor

Study Record Dates

• First Submitted: August 20, 2008
• First Posted: August 22, 2008
• Study Start: June 1, 2007
• Primary Completion: September 1, 2011
• Study Completion: September 1, 2011
• Last Updated: October 4, 2011

Record last verified: 2011-10

Locations

CA (1)