Effect of Dexamethasone on Migraine Headache
The Effect of Dexamethasone in the Attack of Migraine Headache and to Prevent of Its Relapse After Discharge From Emergency Department: a Randomized, Double-Blind, Controlled Trial.
1 other identifier
interventional
30
1 country
1
Brief Summary
Dexamethasone is a safe and cheap abortive therapy for migraine headache. The effect of it is never evaluate and not correlate with the effect of popular anti migraine medication such as dihydroergotamine. The investigators proposal is to compare its effect with dihydroergotamine.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Feb 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 11, 2008
CompletedFirst Posted
Study publicly available on registry
August 13, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2009
CompletedAugust 13, 2008
August 1, 2008
10 months
August 11, 2008
August 11, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
to evaluate the efficacy of dexamethazone in abortive therapy of migraine attack and prevent of recurrence
Study Arms (2)
1
EXPERIMENTAL2
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Migraine attack according to international headache society criteria
- Migraine without aura; at least 5 attack with mean duration of 4 to 72 hours and 2 of following:
- Unilateral
- Pulsatile
- Severe enough to impair daily activity
- Aggravate with walking and climbing, also 1 of following:
- Nausea and or vomiting
- Photophobia and phonophobia, and not contributed to other headache.
- Migraine with aura; at least 2 attacks with 3 of following:
- One reversible aura
- Aura became apparent at least in 4 minutes
- Aura not lasting more than 60 minutes
- Headache develops in less than 60 minutes after aura
You may not qualify if:
- Hypertension
- Ischemic heart disease
- Basilar migraine with sign and symptoms such as:
- Diplopia
- Ataxia
- Dysarthria
- Dysphagia
- Weakness
- Sensory disorder
- Drowsiness
- Peripheral vascular disease
- Sepsis
- Age more than 40 and less than 15 year old
- Pregnancy
- Use of triptans and ergots derivatives in past 24 hours
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Peyman Petramfar
Shiraz, Fars, Iran
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
August 11, 2008
First Posted
August 13, 2008
Study Start
February 1, 2008
Primary Completion
December 1, 2008
Study Completion
August 1, 2009
Last Updated
August 13, 2008
Record last verified: 2008-08