Effect of Passive Exercise on Systemic Endothelial Function in Elderly Patients With Chronic Heart Failure
1 other identifier
interventional
30
1 country
1
Brief Summary
The purpose of this study is to determine the effect of passive exercise on systemic endothelial function in elderly patients with chronic heart failure.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4
Started Aug 2008
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedFirst Submitted
Initial submission to the registry
August 11, 2008
CompletedFirst Posted
Study publicly available on registry
August 12, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedOctober 4, 2023
October 1, 2023
1.6 years
August 11, 2008
October 2, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Endothelial function
2 weeks
Secondary Outcomes (2)
Left ventricular systolic and diastolic function
2 weeks
Six-minute walk distance
2 weeks
Study Arms (2)
1
ACTIVE COMPARATORPassive leg cycle exercise with stretching and resistance training
2
ACTIVE COMPARATORStretching and resistance training
Interventions
Passive leg cycle exercise for 15 minutes everyday as well as stretching and resistance training
Stretching and resistance training everyday but no Passive leg cycle exercise
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of chronic heart failure
- Elderly patients aged ≧65 years
- Patients with severely reduced exercise capacity and cannot continue exercise with usual cycling ergometer for 5 minutes
You may not qualify if:
- Unstable hemodynamic status (uncontrolled arrhythmia, uncontrolled congestion, uncontrolled hypertension)
- Active infectious disease
- Malignancy
- Chronic obstructive pulmonary disease
- Dialysis
- Severe aortic valve disease
- With any hip, knee, ankle joint pain
- Hemiplegia
- Current smoker
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Kyoto Universitylead
Study Sites (1)
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Kyoto, 606-8507, Japan
Related Publications (1)
Ozasa N, Morimoto T, Bao B, Shioi T, Kimura T. Effects of machine-assisted cycling on exercise capacity and endothelial function in elderly patients with heart failure. Circ J. 2012;76(8):1889-94. doi: 10.1253/circj.cj-11-1113. Epub 2012 May 16.
PMID: 22664754DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Takeshi Kimura, MD, PhD
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Investigator
Study Record Dates
First Submitted
August 11, 2008
First Posted
August 12, 2008
Study Start
August 1, 2008
Primary Completion
March 1, 2010
Study Completion
March 1, 2010
Last Updated
October 4, 2023
Record last verified: 2023-10