NCT00722397|CompletedDMC
TODAY Genetics Study
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Genetics Study
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Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Genetics Study
Sponsor study identifier
Secondary identifiers
observational
2,654
1 country
25
Study Start
August 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2015
Actual (reported)Study Completion
February 2015
Actual (reported)The TODAY study group has prepared a protocol with the primary objective of collecting blood and phenotypic information to be used to explore relationships between candidate genes and type 2 diabetes (T2D), as well as obesity, insulin resistance, and cardiovascular complications of insulin resistance. Participation in the genetics study includes a blood draw for analysis of diabetes type and DNA extraction, as well as collection of basic family and medical history. Appropriate informed consent and assent are obtained from all participants to extract DNA and send blood, genetic material, and medical history to the Central Repository of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH). The data are kept indefinitely by the Central Repository. The NIDDK will issue requests for proposals (RFP) throughout the scientific community for research that may help in the development of new diagnostic tests, new treatments, and new ways to prevent diabetes and other related comorbidities.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 23, 2008
Actual (reported)July 25, 2008
Actual (reported)August 2008
Date type not reportedThis date has not been verified as actual or estimated.
February 2015
Actual (reported)February 2015
Actual (reported)Blood draw to be processed and analyzed to yield genetic data.
Blood is sent to the DNA processing center identified by NIDDK for processing and shipment to the NIDDK Repository.
Blood is drawn at the single study visit.
Phenotype data.
Collected at single study visit.
Laboratory values.
Single study visit.
Recruitment is conducted within a 'catchment' area that includes (a) the patient pools of the 15 TODAY clinical centers and (b) collaborating clinics and physicians who either refer subjects to a TODAY site or obtain IRB approval to conduct the protocol at their own locale.
UAMS Arkansas Children's Hospital
Little Rock, Arkansas, 72202, United States
Childrens Hospital Los Angeles
Los Angeles, California, 90027, United States
UCSD Rady Children's Hospital
San Diego, California, 92123, United States
University of Colorado Denver
Aurora, Colorado, 80045, United States
Connecticut Children's Medical Center
Hartford, Connecticut, 06106, United States
Yale University
New Haven, Connecticut, 06519, United States
University of Florida
Gainesville, Florida, 32611, United States
Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, Dabelea D, Florez JC; ProDiGY Consortium. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes. 2021 Apr;70(4):996-1005. doi: 10.2337/db20-0443. Epub 2021 Jan 21.
Collect 27 mL of blood to send (1) for extraction of DNA to the NIDDK Central Repository and (2) for measurement of glucose, C-peptide, and autoantibody analysis to a central blood laboratory.
Phil Zeitler, MD PhD
University of Colorado, Denver
Kathryn Hirst, PhD
George Washington University
2,654 participants (actual enrollment reported by the registry).
First Submitted
July 23, 2008
First Posted
July 25, 2008
Study Start
August 2008
Date type not reportedThis date has not been verified as actual or estimated.
Quitting Caffeine for Better Glucose Metabolism
Contact the study team to confirm eligibility.
Emory University
Atlanta, Georgia, 30322, United States
Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
George Washington University Biostatistics Center
Rockville, Maryland, 20852, United States
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
Joslin Diabetes Center
Boston, Massachusetts, 02215, United States
Kansas City Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
St Louis University
St Louis, Missouri, 63104, United States
Washington University
St Louis, Missouri, 63110, United States
Columbia University
New York, New York, 10032, United States
State University of New York Upstate Medical University
Syracuse, New York, 13214, United States
Case Western Reserve University
Cleveland, Ohio, 44106, United States
University of Oklahoma
Oklahoma City, Oklahoma, 73117, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Baylor College of Medicine
Houston, Texas, 77030, United States
Texas Tech University Health Science Center
Lubbock, Texas, 79430, United States
University of Texas Health Science Center
San Antonio, Texas, 78207, United States
Primary Completion
February 2015
Actual (reported)Study Completion
February 2015
Actual (reported)Last Updated
August 4, 2021
Record last verified: 2021-07
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Source: ClinicalTrials.gov.
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