NCT00721708

Brief Summary

The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Apr 2007

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2007

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2007

Completed
9 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
21 days until next milestone

First Submitted

Initial submission to the registry

July 22, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 24, 2008

Completed
Last Updated

December 15, 2009

Status Verified

December 1, 2009

Enrollment Period

6 months

First QC Date

July 22, 2008

Last Update Submit

December 14, 2009

Conditions

Oxidative Stress

Keywords

histidine dipeptidescarnosineanserine

Outcome Measures

Primary Outcomes (1)

  • Plasma histidine-dipeptide

    0, 30, 60, 100, 180, 240, & 300 min

Study Arms (4)

1

EXPERIMENTAL

Carnosine(450 mg)

Dietary Supplement: pure carnosine

2

EXPERIMENTAL

Beef (150g)

Other: Beef

3

EXPERIMENTAL

chicken (150g)

Other: Chicken

4

EXPERIMENTAL

Chicken broth (obtained from 150 g of chicken breast)

Other: Chicken broth

Interventions

pure carnosineDIETARY_SUPPLEMENT

one time dose of pure carnosine (450 mg)

1
BeefOTHER

one time dose, 150 g of beef

2
ChickenOTHER

One time dose, 150g of chicken breast

3
Chicken brothOTHER

one time dose of chicken broth obtained from 150g of chicken breast

4

Eligibility Criteria

Age40 Years - 70 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Healthy adult
  • normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

You may not qualify if:

  • History of smoking or alcoholism

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University

Boston, Massachusetts, 02111, United States

Location

Related Publications (1)

  • Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini G. Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans. Amino Acids. 2010 Mar;38(3):847-58. doi: 10.1007/s00726-009-0291-2. Epub 2009 Apr 19.

    PMID: 19381778RESULT

MeSH Terms

Interventions

Red Meat

Intervention Hierarchy (Ancestors)

MeatFoodDiet, Food, and NutritionPhysiological PhenomenaFood and Beverages

Study Officials

  • Kyung-Jin Yeum, Ph.D.

    Tufts Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Masking
NONE
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

July 22, 2008

First Posted

July 24, 2008

Study Start

April 1, 2007

Primary Completion

October 1, 2007

Study Completion

July 1, 2008

Last Updated

December 15, 2009

Record last verified: 2009-12

Locations

US(1)