NCT00718796

Brief Summary

This study is designed to test the ability of a comprehensive naturopathic approach to reduce important risk factors for the development of cardiovascular disease. Treatment will take place over the course of one year and the comparator/control group will be followed by their medical doctors and be given conventional care.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Apr 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
24 days until next milestone

First Submitted

Initial submission to the registry

April 25, 2008

Completed
3 months until next milestone

First Posted

Study publicly available on registry

July 21, 2008

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2009

Completed
Last Updated

May 17, 2010

Status Verified

May 1, 2010

Enrollment Period

1.5 years

First QC Date

April 25, 2008

Last Update Submit

May 14, 2010

Conditions

Keywords

cardiovascular diseasenaturopathic medicinenatural health productslifestyle interventiondietary advicecoronary heart disease

Outcome Measures

Primary Outcomes (2)

  • Metabolic syndrome

    1 year

  • General Cardiovascular Risk Profile: Framingham Heart Study

    1 year

Secondary Outcomes (4)

  • Adverse events

    1 year

  • HbA1C

    1 year

  • Compliance with naturopathic interventions

    1 year

  • Quality of Life (Short-form 36)

    1 year

Study Arms (2)

1

EXPERIMENTAL

Individualized naturopathic treatment consisting of dietary and lifestyle advice and individualized supplementation

Other: Naturopathic medicine. May include: fish oil, plant sterols, soluble fiber, cinnamon, coQ10 and exercise

2

ACTIVE COMPARATOR

Current care control provided by participants' medical doctor

Other: Conventional medical treatment (Atorvastatin,Fluvastatin,Lovastatin,Pravastatin,Rosuvastatin,Simvastatin)

Interventions

Individualized according to needs of each participant and willingness to comply. Intervention to include lifestyle modification, dietary changes and supplementation using natural health products as recommended by naturopathic practitioner.

Also known as: Naturopthic Medicine, Diet, Natural Health Products, Alternative Medicine, Fish oil, Plant sterols, Soluble fiber, CoQ10, Cinnamon, Exercise
1

Will vary according to individual - not standardized and likely to include statins.

Also known as: Cholesterol lowering drugs, Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin
2

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • to 65 years old
  • CUPW worker
  • prescreening indicates higher than normal TC/HDL ratio

You may not qualify if:

  • Experienced an MI or stroke within past 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Canadian College of Naturopathic Medicine

Toronto, Ontario, M2K 1E2, Canada

Location

Related Publications (2)

  • Herman PM, Szczurko O, Cooley K, Seely D. A naturopathic approach to the prevention of cardiovascular disease: cost-effectiveness analysis of a pragmatic multi-worksite randomized clinical trial. J Occup Environ Med. 2014 Feb;56(2):171-6. doi: 10.1097/JOM.0000000000000066.

  • Seely D, Szczurko O, Cooley K, Fritz H, Aberdour S, Herrington C, Herman P, Rouchotas P, Lescheid D, Bradley R, Gignac T, Bernhardt B, Zhou Q, Guyatt G. Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ. 2013 Jun 11;185(9):E409-16. doi: 10.1503/cmaj.120567. Epub 2013 Apr 29.

Related Links

MeSH Terms

Conditions

Cardiovascular DiseasesCoronary Disease

Interventions

Phytosterolscoenzyme Q10ExerciseDietComplementary TherapiesFish OilsAtorvastatinAnticholesteremic AgentsFluvastatinLovastatinPravastatinRosuvastatin CalciumSimvastatin

Condition Hierarchy (Ancestors)

Myocardial IschemiaHeart DiseasesVascular Diseases

Intervention Hierarchy (Ancestors)

SterolsCholestanesSteroidsFused-Ring CompoundsPolycyclic CompoundsMembrane LipidsLipidsPhytochemicalsBiological FactorsMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological PhenomenaNutritional Physiological PhenomenaDiet, Food, and NutritionPhysiological PhenomenaTherapeuticsOilsPyrrolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsHeptanoic AcidsFatty AcidsHypolipidemic AgentsAntimetabolitesMolecular Mechanisms of Pharmacological ActionPharmacologic ActionsChemical Actions and UsesLipid Regulating AgentsTherapeutic UsesIndolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingNaphthalenesPolycyclic Aromatic HydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsSulfonamidesAmidesFluorobenzenesHydrocarbons, FluorinatedHydrocarbons, HalogenatedSulfonesSulfur CompoundsPyrimidines

Study Officials

  • Dugald Seely, ND

    Canadian College of Naturopathic Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

April 25, 2008

First Posted

July 21, 2008

Study Start

April 1, 2008

Primary Completion

October 1, 2009

Study Completion

October 1, 2009

Last Updated

May 17, 2010

Record last verified: 2010-05

Locations