NCT00712543

Brief Summary

This study will evaluate whether patients have an overall preference for Kristalose® or liquid lactulose based on taste, consistency, and portability.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for phase_4

Timeline
Completed

Started Jun 2009

Shorter than P25 for phase_4

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 8, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 10, 2008

Completed
11 months until next milestone

Study Start

First participant enrolled

June 1, 2009

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2009

Completed
2.1 years until next milestone

Results Posted

Study results publicly available

September 27, 2011

Completed
Last Updated

September 27, 2011

Status Verified

August 1, 2011

Enrollment Period

3 months

First QC Date

July 8, 2008

Results QC Date

April 7, 2011

Last Update Submit

August 19, 2011

Conditions

Keywords

constipationlaxativelactuloseKristalose®

Outcome Measures

Primary Outcomes (1)

  • Patient Preference in Terms of Overall Preference and Preference of Taste, Consistency, and Portability.

    14 days

Study Arms (2)

1

EXPERIMENTAL

Kristalose®, as prescribed, for 7 days.

Drug: lactulose (Kristalose®)

2

EXPERIMENTAL

Liquid lactulose, as prescribed, for 7 days.

Drug: liquid lactulose

Interventions

Crystals to be dissolved in water and taken as prescribed.

Also known as: Kristalose®
1

Liquid to be taken as prescribed.

2

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with recently diagnosed chronic constipation requiring treatment.

You may not qualify if:

  • Patients with galactosemia (galactose-sensitive diet).
  • Patients less than 18 years of age.
  • Patients currently on lactulose therapy.
  • Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by an Institutional Review Board \[IRB\]) and agree to abide by the study restrictions.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Arya Gastroenterology Associates

Brooklyn, New York, 11237, United States

Location

Wake Research Associates

Raleigh, North Carolina, 27612, United States

Location

Rapid Medical Research

Cleveland, Ohio, 44122, United States

Location

MeSH Terms

Conditions

Constipation

Interventions

Lactulose

Condition Hierarchy (Ancestors)

Signs and Symptoms, DigestiveSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

DisaccharidesOligosaccharidesPolysaccharidesCarbohydratesSugars

Results Point of Contact

Title
Bryan Voss, Ph.D.
Organization
Cumberland Pharmaceuticals Inc.

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 8, 2008

First Posted

July 10, 2008

Study Start

June 1, 2009

Primary Completion

September 1, 2009

Study Completion

September 1, 2009

Last Updated

September 27, 2011

Results First Posted

September 27, 2011

Record last verified: 2011-08

Locations