Propofol Versus Volatile Anesthesia in Post Operative Pain Management

NCT00712517 | Terminated

• 1 other identifier: 42908
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The study will test the hypothesis that patients anesthetized with propofol suffer less postoperative pain than those anesthetized with sevoflurane.

Conditions

Varicose Vein; Postoperative Pain

Keywords

postoperative pain; Piritramid; propofol; sevoflurane; varicose vein; Anesthesia

Outcome Measures

Primary Outcomes (1)

• The primary outcome is morphine-equivalent use from the end of surgery until the first post-operative morning.

  first post operative morning

Secondary Outcomes (1)

• To determine the average pain score for each group during the first four hours of recovery after surgery.

  30 minute intervals for first 4 hours post operatively

Study Arms (2)

1

ACTIVE COMPARATOR

Patients will receive propofol anesthesia during varicose vein stripping surgery.

Drug: propofol

2

ACTIVE COMPARATOR

Patients will receive sevoflurane anesthesia during varicose vein stripping surgery.

Drug: sevoflurane

Interventions

propofol DRUG

propofol anesthesia 3-5mg/kg

Also known as: Diprivan

1

sevoflurane DRUG

sevoflurane anesthesia

2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants will undergo a stripping operation for varicose veins
• Surgery will be performed by one physician only
• Written informed consent

You may not qualify if:

• Any contraindications to the proposed interventions
• Procedures done under regional anesthesia

Sponsors & Collaborators

• The Cleveland Clinic: lead

Study Sites (1)

Olga Plattner , MD

Vienna, Austria

Location

Related Publications (1)

• Windpassinger M, Plattner O, Gemeiner J, Bohler K, Luntzer R, Klimscha W, Yang D, Mascha EJ, Sessler DI. Opioid use after propofol or sevoflurane anesthesia: a randomized trial. Can J Anaesth. 2016 Nov;63(11):1258-65. doi: 10.1007/s12630-016-0728-5. Epub 2016 Sep 14.

  PMID: 27638296 DERIVED

MeSH Terms

Conditions

Varicose Veins; Pain, Postoperative

Interventions

Propofol; Sevoflurane

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Methyl Ethers; Ethers; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated

Study Officials

• Olga Plattner, MD

  Medical University of Vienna

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 7, 2008
• First Posted: July 10, 2008
• Study Start: September 1, 2010
• Primary Completion: May 1, 2014
• Study Completion: May 1, 2014
• Last Updated: July 20, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)