NCT00708669

Brief Summary

To evaluate the procedural, short and long term clinical outcomes of the TAXUS stent compared to Cypher stent in coronary arteries of ≥ 2.5 and ≤ 3.75 mm in the reference vessel diameter with a lesion of ≤ 46 mm (by visual observation) in routine clinical settings in Japan.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,500

participants targeted

Target at P75+ for not_applicable coronary-artery-disease

Geographic Reach
1 country

122 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2008

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

June 30, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

July 2, 2008

Completed
5.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2013

Completed
Last Updated

November 5, 2014

Status Verified

April 1, 2012

Enrollment Period

5.5 years

First QC Date

June 30, 2008

Last Update Submit

November 4, 2014

Conditions

Outcome Measures

Primary Outcomes (1)

  • Target Vessel Failure (TVF) at 8 months post-procedure(assessed prior to routine angiography) in Overall study population

    8 months

Secondary Outcomes (1)

  • Target Vessel Failure (TVF) at 8 months post-procedure (assessed prior to routine angiography) in diabetic group

    8 months

Study Arms (2)

TAXUS group

ACTIVE COMPARATOR
Device: TAXUS stent

Cypher group

ACTIVE COMPARATOR
Device: Cypher stent

Interventions

Compared two kinds of stents:TAXUS stent, approved for commercialization in Japan(March 30th, 2007)

TAXUS group

CYPHER stent, approved for commercialization in Japan(March 25, 2004)

Cypher group

Eligibility Criteria

Age20 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patient is ≥ 20 years old
  • Patient suitable for percutaneous coronary intervention (PCI)
  • Patient with signed informed consent
  • Patient judged suitable to receive anti-platelet drugs (clopidogrel bisulfate or ticlopidine hydrochloride, etc.) in principle for at least 6 months after procedure, and ideally up to 12 months in patients who are not at high risk of bleeding, based on ACC/AHA guideline
  • Patient with up to 3 lesions (with ≥ 50% of stenosis) in the maximum of 2 targeted vessels to be treated at once
  • Patient with reference vessel diameter (RVD) of 2.5 mm to 3.75 mm by visual observation
  • Patient with length of each lesion of up to 46 mm by visual assessment
  • Patient eligible for implementation of drug eluting stent.

You may not qualify if:

  • Patient with any planned treatment in the targeted vessel with a drug eluting stent other than in this study
  • Patient with acute myocardial infarction (AMI) (including non-ST segment elevation MI) developed within 7 days before the procedure
  • Patient participating in a currently ongoing registry or clinical study, or receiving a treatment which may affect the endpoints of this study
  • Patient of childbearing potential with a positive pregnancy test within 14 days before the procedure, or lactating
  • Patient who has history of allergy against Sirolimus, Paclitaxel, polymers or stainless steel
  • Patient who has history of side-effect against anti-platelet drugs or anti-coagulation drugs
  • Patient with serious hepatic dysfunction
  • Patient with left ventriculogram ejection fraction of 35% or less
  • Patient with three target vessels in need of PCI treatment
  • Patient with serious renal dysfunction (serum creatinine value 2mg/dL or higher)
  • Patient currently receiving artificial dialysis
  • Patient with a malignant tumor (cancer) diagnosed within 5 years before the procedure
  • Patient who has received PCI treatment within the past one year
  • Patient with chronic total occlusion (CTO) or TIMI flow 2 or less
  • Patient with \>50% stenosis in left main coronary artery
  • +4 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (122)

Aichi Medical University Hospital

Aichi, Japan

Location

Japan Labour Health and Welfare Organization, Kansai Rosai Hospital

Amagasaki, Japan

Location

Asahikawa-Kosei General Hospital

Asahikawa, Japan

Location

Sakakibara Memorial Hospital

Fuchū, Japan

Location

Fukui Cardiovascular Center

Fukui, Japan

Location

Fukuoka University Hospital

Fukuoka, Japan

Location

Gifu Prefectural General Medical Center

Gifu, Japan

Location

Seirei Hamamatsu General Hospital

Hamamatsu, Japan

Location

Hekinan Municipal Hospital

Hekinan, Japan

Location

Saitama Medical University International Medical Center

Hidaka, Japan

Location

Koto Memorial Hospital

Higashiōmi, Japan

Location

Kansai Medical University Hirakata Hospital

Hirakata, Japan

Location

Hiratsuka Kyosai Hospital

Hiratsuka, Japan

Location

Hirosaki University School of Medicine and Hospital

Hirosaki, Japan

Location

Hiroshima University Hospital

Hiroshima, Japan

Location

Tsuchiya General Hospital

Hiroshima, Japan

Location

Iizuka Hospital

Iizuka, Japan

Location

Saiseikai Imabari Hospital

Imabari, Japan

Location

Nippon Medical School Chiba Hokusoh Hospital

Inzai, Japan

Location

Iwaki Kyoritsu Hospital

Iwaki, Japan

Location

Rinku General Medical Center

Izumisano, Japan

Location

Juntendo University Shizuoka Hospital

Izunokuni, Japan

Location

Setsunan General Hospital

Kadoma, Japan

Location

Ishikawa Prefectural Central Hospital

Kanazawa, Japan

Location

Kanazawa Cardiovascular Hospital

Kanazawa, Japan

Location

Nara Medical University Hospital

Kashihara, Japan

Location

Japan Labour Health and Welfare Organization, Kanto Rosai Hospital

Kawasaki, Japan

Location

Kawasaki Saiwai Hospital

Kawasaki, Japan

Location

Kagawa University Hospital

Kida, Japan

Location

Kimitsu Chuo Hospital

Kisarazu, Japan

Location

Kokura Memorial Hospital

Kitakyushu, Japan

Location

Kobe University Hospital

Kobe, Japan

Location

Chikamori Hospital

Kochi, Japan

Location

Hoshi General Hospital

Kōriyama, Japan

Location

Kumamoto Chuo Hospital

Kumamoto, Japan

Location

Saiseikai Kumamoto Hospital

Kumamoto, Japan

Location

Kawasaki Medical School Hospital

Kurashiki, Japan

Location

Kurume University Hospital

Kurume, Japan

Location

St.Mary's Hospital

Kurume, Japan

Location

Japanese Red Cross Kyoto Daini Hospital

Kyoto, Japan

Location

Koseikai Takeda Hospital

Kyoto, Japan

Location

Kyoto-Katsura Hospital

Kyoto, Japan

Location

Mie Heart Center

Mie, Japan

Location

Miki City Hospital

Miki, Japan

Location

Miyazaki Medical Association Hospital

Miyazaki, Japan

Location

Memorial Heart Center Iwate Medical University

Morioka, Japan

Location

Shiga Medical Center for Adults

Moriyama, Japan

Location

Musashino Red Cross Hospital

Musashino, Japan

Location

Tachikawa General Hospital

Nagaoka, Japan

Location

Kouseikai Hospital

Nagasaki, Japan

Location

Nagoya daiichi red cross Hospital

Nagoya, Japan

Location

Nagoya Daini Red Cross Hospital

Nagoya, Japan

Location

Nagoya Memorial Hospital

Nagoya, Japan

Location

Okayama Red Cross General Hospital

Okayama, Japan

Location

Okayama University Hospital

Okayama, Japan

Location

Sakakibara Heart Institute of Okayama

Okayama, Japan

Location

National Hospital Organization Osaka National Hospital

Osaka, Japan

Location

Osaka City University Hospital

Osaka, Japan

Location

Osaka General Medical Center

Osaka, Japan

Location

Osaka Police Hospital

Osaka, Japan

Location

Ogaki Municipal Hospital

Ōgaki, Japan

Location

Oita Cardiovascular Hospital

Ōita, Japan

Location

OitaOka Hospital

Ōita, Japan

Location

Omihachiman Community Medical Center

Ōmihachiman, Japan

Location

Kitasato University Hospital

Sagamihara, Japan

Location

Iwatsuki-minami Hospital

Saitama, Japan

Location

Japan Labour Health and Welfare Organization, Osaka Rosai Hospital

Sakai, Japan

Location

Caress Sapporo Hokko Memorial Hospital

Sapporo, Japan

Location

Caress Sapporo Tokeidai Hospital

Sapporo, Japan

Location

Hokkaido Social Insurance Hospital

Sapporo, Japan

Location

Sapporo Orthopaedic Cardio-vascular Hospital

Sapporo, Japan

Location

Teine Keijinkai Hospital

Sapporo, Japan

Location

Sendai Kousei Hospital

Sendai, Japan

Location

Sendai Open Hospital

Sendai, Japan

Location

Tohoku Koseinenkin Hospital

Sendai, Japan

Location

Jichi Medical University Hospital

Shimotsuke, Japan

Location

National Cerebral and Cardiovascular Center

Suita, Japan

Location

Osaka University Graduate School of Medicine

Suita, Japan

Location

Kagawa Prefectural Central Hospital

Takamatsu, Japan

Location

Ayase Heart Hospital

Tokyo, Japan

Location

Edogawa Hospital

Tokyo, Japan

Location

Itabashi Chuo Medical Center

Tokyo, Japan

Location

Jikei University Hospital

Tokyo, Japan

Location

Juntendo University Hospital

Tokyo, Japan

Location

Juntendo University Nerima Hospital

Tokyo, Japan

Location

Kanto Medical Center NTT EC

Tokyo, Japan

Location

Keio University Hospital

Tokyo, Japan

Location

Mitsui Memorial Hospital

Tokyo, Japan

Location

Nihon University School of Medicine Itabashi Hospital

Tokyo, Japan

Location

Nippon Medical School Hospital

Tokyo, Japan

Location

Showa University Hospital

Tokyo, Japan

Location

St. Luke's International Hospital

Tokyo, Japan

Location

Teikyo University Hospital

Tokyo, Japan

Location

The Cardiovascular Institute Hospital

Tokyo, Japan

Location

Toho University Ohashi Medical Center

Tokyo, Japan

Location

Toho University Omori Medical Center

Tokyo, Japan

Location

Tokyo Medical University Hospital

Tokyo, Japan

Location

Tokyo Metropolitan Hiroo Hospital

Tokyo, Japan

Location

Tokyo Women's Medical University Hospital

Tokyo, Japan

Location

Toranomon Hospital

Tokyo, Japan

Location

Tomishiro Central Hospital

Tomishiro, Japan

Location

Toyama Prefectural Central Hospital

Toyama, Japan

Location

Toyama Red Cross Hospital

Toyama, Japan

Location

Fujita Health University Hospital

Toyoake, Japan

Location

Toyohashi Heart Center

Toyohashi, Japan

Location

Tsuchiura Kyodo Hospital

Tsuchiura, Japan

Location

Tsuyama Central Hospital

Tsuyama, Japan

Location

Uwajima City Hospital

Uwajima, Japan

Location

Wakayama Medical University Hospital

Wakayama, Japan

Location

Yamagata Prefectural Central Hospital

Yamagata, Japan

Location

Saiseikai Yamaguchi Hospital

Yamaguchi, Japan

Location

Japan Labour Health and Welfare Organization, Kumamoto Rosai hospital

Yatsushiro, Japan

Location

Japan Labour Health and Welfare Organization, Yokohama Rosai Hospital

Yokohama, Japan

Location

Kanagawa Cardiovascular and Respiratory Center

Yokohama, Japan

Location

Kikuna Memorial Hospital

Yokohama, Japan

Location

Saiseikai Yokohamashi Tobu Hospital

Yokohama, Japan

Location

Showa University Fujigaoka Hospital

Yokohama, Japan

Location

Showa University Northern Yokohama Hospital

Yokohama, Japan

Location

Yokohama City University General Medical Center

Yokohama, Japan

Location

Yokohama Sakae Kyosai Hospital

Yokohama, Japan

Location

Yokosuka General Hospital Uwamachi

Yokosuka, Japan

Location

Tottori University Hospital

Yonago, Japan

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Shinsuke Nanto, M.D

    Non-profit organization(NPO); "Associations for Establishment of Evidence in Intervations"

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 30, 2008

First Posted

July 2, 2008

Study Start

March 1, 2008

Primary Completion

September 1, 2013

Last Updated

November 5, 2014

Record last verified: 2012-04

Locations