Multidetector Raw CT as a Single Tool in the Setting of Ischemic Stroke
COCASE
Evaluation of Multidetector Raw Computerized Tomography in the Etiological Analysis of Acute Ischemic Stroke: the "COCASE" Protocol.
1 other identifier
interventional
49
1 country
1
Brief Summary
This is a prospective study including acute ischemic stroke patients aged 18 to 90. Multidetector raw CT is performed in acute ischemic stroke patients. Heart, neck vessels and brain arteries are studied during the same acquisition. Results are compared with the standard methods including transesophageal echocardiography (TEE), Doppler ultrasound (DUS) and MR angiography (MRA) of neck vessels. The main criteria is the ability of CT to classify the stroke etiology correctly according to the TOAST classification in comparison with the standard methods.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Mar 2008
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2008
CompletedFirst Submitted
Initial submission to the registry
June 30, 2008
CompletedFirst Posted
Study publicly available on registry
July 2, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedMay 28, 2019
July 1, 2013
5.1 years
June 30, 2008
May 23, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Ability of CT to classify the stroke etiology correctly (TOAST classification) in comparison to reference methods (MRA, DUS, TEE)
classify the stroke etiology
Secondary Outcomes (1)
Ability of CT to detect the source of stroke in each etiological group. Reliability of CT in quantitative measures of artery stenosis, aortic atheroma, heart thrombus, heart tumors). Tolerance of CT
detect the source of stroke
Study Arms (1)
Multidetector raw CT
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- Acute (\< 1 week) ischemic stroke patient aged 18 to 90
- Informed consent obtained
- Presence of health insurance
You may not qualify if:
- Pregnancy or absence of efficient contraceptive method
- Allergy
- Allergy to contrast material
- Asthma
- Renal failure (blood creatinine \> 130 µmoles/l, creatinine clearance \< 80 ml/mn according to Cockroft method)
- Myeloma
- Hyperthyroidism (uncontrolled)
- Difficulties to synchronize CT to heart rhythm
- Contra-indication to TEE or MRI
- Absence or retirement of informed consent
- Absence of health insurance
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hôpital Cardiologique Louis Pradel
Bron, 69677, France
Related Publications (1)
Boussel L, Cakmak S, Wintermark M, Nighoghossian N, Loffroy R, Coulon P, Derex L, Cho TH, Douek PC. Ischemic stroke: etiologic work-up with multidetector CT of heart and extra- and intracranial arteries. Radiology. 2011 Jan;258(1):206-12. doi: 10.1148/radiol.10100804. Epub 2010 Nov 9.
PMID: 21062925RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
DOUEK Philippe, MD
Hospices Civils de Lyon
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 30, 2008
First Posted
July 2, 2008
Study Start
March 1, 2008
Primary Completion
April 1, 2013
Study Completion
April 1, 2013
Last Updated
May 28, 2019
Record last verified: 2013-07