NCT00704067

Brief Summary

The 12-month study will investigate a cognitive training augmentation of supported employment to improve cognitive performance and work outcomes, which are expected to result in improved quality of life and community integration for veterans with mild to moderate traumatic brain injuries. The primary hypothesis is that compared to veterans who receive enhanced supported employment, those who receive supported employment plus cognitive training will work more weeks during the 12 months.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2008

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 20, 2008

Completed
4 days until next milestone

First Posted

Study publicly available on registry

June 24, 2008

Completed
2 months until next milestone

Study Start

First participant enrolled

September 1, 2008

Completed
3.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2012

Completed
Last Updated

February 12, 2015

Status Verified

February 1, 2015

Enrollment Period

3.9 years

First QC Date

June 20, 2008

Last Update Submit

February 11, 2015

Conditions

Keywords

vocational rehabilitationsupported employmentcognitive trainingcognitive remediationcognitive rehabilitationveterans

Outcome Measures

Primary Outcomes (1)

  • Weeks worked

    12 months

Secondary Outcomes (5)

  • Hours worked

    12 months

  • Dollars earned from working

    12 months

  • Cognitive performance

    3, 6, and 12 months

  • Neurobehavioral symptoms

    3, 6, and 12 months

  • Quality of life

    3, 6, and 12 months

Study Arms (2)

1

EXPERIMENTAL

Supported employment for 12 months plus cognitive training for the first 12 weeks

Behavioral: Supported employment plus cognitive training

2

ACTIVE COMPARATOR

Supported employment for 12 months plus one additional supported employment session per week for the first 12 weeks

Behavioral: Enhanced supported employment

Interventions

Supported employment for 12 months plus cognitive training for the first 12 weeks

1

Supported employment for 12 months plus one additional supported employment session per week for the first 12 weeks.

2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • OEF/OIF veteran
  • History of mild-to-moderate TBI (loss of consciousness \<6 hours; post-traumatic amnesia \<7 days)
  • Documented impairment in at least one neuropsychological domain
  • Unemployed, but stating a goal of work
  • Written informed consent to participate in the study

You may not qualify if:

  • Current alcohol/substance abuse or dependence
  • Participation in other intervention studies

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA San Diego Healthcare System

San Diego, California, 92161, United States

Location

Related Publications (1)

  • Walter KH, Jak AJ, Twamley EW. Psychiatric comorbidity effects on compensatory cognitive training outcomes for veterans with traumatic brain injuries. Rehabil Psychol. 2015 Aug;60(3):303-8. doi: 10.1037/rep0000049. Epub 2015 Jul 6.

MeSH Terms

Conditions

Brain Injuries, Traumatic

Interventions

Employment, SupportedCognitive Training

Condition Hierarchy (Ancestors)

Brain InjuriesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesCraniocerebral TraumaTrauma, Nervous SystemWounds and Injuries

Intervention Hierarchy (Ancestors)

EmploymentSocioeconomic FactorsPopulation CharacteristicsRehabilitation, VocationalRehabilitationHealth ServicesHealth Care Facilities Workforce and ServicesNeurological RehabilitationAftercareContinuity of Patient CarePatient CareTherapeutics

Study Officials

  • Elizabeth W Twamley, PhD

    University of California, San Diego, VA San Diego Healthcare System, and Veterans Medical Research Foundation

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 20, 2008

First Posted

June 24, 2008

Study Start

September 1, 2008

Primary Completion

August 1, 2012

Study Completion

August 1, 2012

Last Updated

February 12, 2015

Record last verified: 2015-02

Locations