NCT00699868

Brief Summary

This prospective study evaluate the immune status of patients admitted in ICU.CMV remains dormant in the body, but in people with immune deficiency, CMV could reactivate and cause life-threatening pneumonia.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
29

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2008

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2008

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

June 13, 2008

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 18, 2008

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2011

Completed
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2011

Completed
Last Updated

June 4, 2012

Status Verified

June 1, 2012

Enrollment Period

2.8 years

First QC Date

June 13, 2008

Last Update Submit

June 1, 2012

Conditions

Cytomegalovirus Infection

Outcome Measures

Primary Outcomes (1)

  • Bring to light the quantitative and qualitative immunological modifications of the present cells NK before the arisen of an infection to CMV

    24 months

Secondary Outcomes (1)

  • Bring to light the quantitative and qualitative immunological modifications of cells NK in the consequences of an infectious shock

    24 months

Study Arms (2)

1

EXPERIMENTAL

Infection to CMV

Other: Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markings

2

OTHER

Group "control CMV"

Other: Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markings

Interventions

Sampling of blood, phenotypic analysis sub-populations NK by cytometric of stream in multiple markingsOTHER

Sampling of blood

1

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age more than 18-year-old
  • Informed consent

You may not qualify if:

  • minors,
  • pregnant or lactating women,
  • adults under guardianship,
  • immunosuppression at the entrance to resuscitation,
  • AIDS

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hôpital de Sainte Marguerite- Service de Réanimation Médicale

Marseille, 13009, France

Location

Related Publications (2)

  • Matta J, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, Chaussabel D, Ugolini S, Vely F, Vivier E. Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood. 2013 Jul 18;122(3):394-404. doi: 10.1182/blood-2013-01-481705. Epub 2013 May 17.

    PMID: 23687088DERIVED

  • Forel JM, Chiche L, Thomas G, Mancini J, Farnarier C, Cognet C, Guervilly C, Daumas A, Vely F, Xeridat F, Vivier E, Papazian L. Phenotype and functions of natural killer cells in critically-ill septic patients. PLoS One. 2012;7(12):e50446. doi: 10.1371/journal.pone.0050446. Epub 2012 Dec 6.

    PMID: 23236375DERIVED

MeSH Terms

Conditions

Cytomegalovirus Infections

Condition Hierarchy (Ancestors)

Herpesviridae InfectionsDNA Virus InfectionsVirus DiseasesInfections

Study Officials

  • Jean-Marie FOREL, MD

    Assistance Publique des Hôpitaux de Marseille

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 13, 2008

First Posted

June 18, 2008

Study Start

March 1, 2008

Primary Completion

January 1, 2011

Study Completion

August 1, 2011

Last Updated

June 4, 2012

Record last verified: 2012-06

Locations

FR(1)