NCT00696189|Terminated
Study Stopped
PI is no longer at this institution
Effects of Nitrous Oxide on Intraocular Pressure
The Effects of Nitrous Oxide on Intraocular Pressure and Ocular Perfusion
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Sponsor study identifier
Secondary identifiers
observational
30
1 country
1
Study Start
September 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2010
Actual (reported)Study Completion
September 2011
Actual (reported)The concept of ocular perfusion pressure (OPP), is defined as the difference between the mean arterial pressure (MAP) and the intraocular pressure (IOP.)It has been hypothesized that unopposed decreases in MAP, increases in IOP or a combination of the two may result in hypo perfusion of the eye and can cause an ocular infarction at the level of the retina or optic nerve, leading to varying degrees of visual loss which is frequently bilateral and irreversible. Both the prone position and downward head tilting (Trendelenburg position) have been associated with increases in IOP compared to the supine horizontal position (2,4,5,6), but it is not known whether the Trendelenburg position during surgery and anesthesia is associated with POVL.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2011
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 2006
Date type not reportedThis date has not been verified as actual or estimated.
June 9, 2008
Actual (reported)June 12, 2008
Actual (reported)September 2010
Actual (reported)September 2011
Actual (reported)Ages of 18 and 65 years of age and mentally capable of giving consent. Scheduled for gynecological surgery and will be placed in the Trendelenburg position (head lower than my waist) on the operating room table.
UMDNJ
Newark, New Jersey, 07101, United States
Geordie Grant, MD
Rutgers, The State University of New Jersey
30 participants (actual enrollment reported by the registry).
First Submitted
June 9, 2008
First Posted
June 12, 2008
Study Start
September 2006
Date type not reportedThis date has not been verified as actual or estimated.
Contact the study team to confirm eligibility.
Primary Completion
September 2010
Actual (reported)Study Completion
September 2011
Actual (reported)Last Updated
April 24, 2015
Record last verified: 2015-04
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Source: ClinicalTrials.gov.
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