NCT00696137

Brief Summary

This study is designed to provide continued access to BEMA Fentanyl for those subjects who previously participated in FEN-202 and who wish to continue using BEMA Fentanyl for the treatment of their breakthrough cancer pain.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5

participants targeted

Target at below P25 for phase_3

Timeline
Completed

Started Jun 2008

Shorter than P25 for phase_3

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2008

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

June 10, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 12, 2008

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2009

Completed
9.5 years until next milestone

Results Posted

Study results publicly available

December 19, 2018

Completed
Last Updated

September 24, 2019

Status Verified

September 1, 2019

Enrollment Period

1.1 years

First QC Date

June 10, 2008

Results QC Date

June 7, 2018

Last Update Submit

September 12, 2019

Conditions

Keywords

Chronic PainVentilatory Response to Hypercapnia (VRH)

Outcome Measures

Primary Outcomes (1)

  • Efficacy Was Not Measured in This Study. The Number of Deaths in the Long Term Follow-up Will be Reported.

    Efficacy was not measured in this study as the intention was to evaluate long term safety in this population. The number of deaths in the long term follow-up will be reported.

    3 years

Study Arms (1)

BEMA Fentanyl

EXPERIMENTAL

BEMA Fentanyl

Drug: BEMA Fentanyl

Interventions

buccal soluble film; 200, 400, 600, 800, and 1200 mcg fentanyl; up to 4 times daily

Also known as: bioerodible mucoadhesive, fentanyl buccal soluble film, ONSOLIS
BEMA Fentanyl

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • previously qualified for and participated in study FEN-202 for at least 2 weeks,
  • wish to continue using BEMA Fentanyl for treatment of breakthrough pain episodes, and
  • provide signed informed consent at screening prior to any study procedures.

You may not qualify if:

  • they have developed a new medical condition after initial enrollment in FEN-202 which, in the opinion of the investigator, would preclude safe and appropriate use of BEMA Fentanyl or participation in this study, or
  • there is evidence of improper use of the study drug.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Respiratory InsufficiencyChronic Pain

Interventions

Fentanyl

Condition Hierarchy (Ancestors)

Respiration DisordersRespiratory Tract DiseasesPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PiperidinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Results Point of Contact

Title
Tim Warneke
Organization
BDSI

Study Officials

  • David Blum, MD

    BioDelivery Sciences International

    STUDY CHAIR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
GT60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 10, 2008

First Posted

June 12, 2008

Study Start

June 1, 2008

Primary Completion

July 1, 2009

Study Completion

July 1, 2009

Last Updated

September 24, 2019

Results First Posted

December 19, 2018

Record last verified: 2019-09