NCT00693108

Brief Summary

it has been shown that androgens in non human primates may favour follicular growth in the ovaries when animals are treated with gonadotropins which are the hormones used in patients receiving treatment with in vitro fertilization. Therefore, this study investigates the potential usefulness of testosterone treatment preceding gonadotropin administration in in vitro fertilization patients having a previous poor response to gonadotropins alone.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2006

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

June 4, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 6, 2008

Completed
Last Updated

June 6, 2008

Status Verified

June 1, 2008

First QC Date

June 4, 2008

Last Update Submit

June 5, 2008

Conditions

Ovarian Response

Keywords

PoorResponseOvarianStimulationIVFPatients

Study Arms (2)

1

EXPERIMENTAL

Transdermal testosterone treatment during the five days preceding gonadotropin therapy in IVF cycles

Drug: Transdermal testosterone

2

NO INTERVENTION

Interventions

Transdermal testosteroneDRUG
1

Eligibility Criteria

Age19 Years - 39 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients receiving the second IVF treatment attempt having the first treatment cycle cancelled because of poor ovarian response to gonadotropins

You may not qualify if:

  • Previous ovarian surgery
  • Clinical or laboratory profile suggesting premature ovarian failure

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital Clinic

Barcelona, 08036, Spain

Location

Related Publications (1)

  • Balasch J, Fabregues F, Penarrubia J, Carmona F, Casamitjana R, Creus M, Manau D, Casals G, Vanrell JA. Pretreatment with transdermal testosterone may improve ovarian response to gonadotrophins in poor-responder IVF patients with normal basal concentrations of FSH. Hum Reprod. 2006 Jul;21(7):1884-93. doi: 10.1093/humrep/del052. Epub 2006 Mar 3.

    PMID: 16517559BACKGROUND

Study Design

Study Type
interventional
Phase
phase 3
Sponsor Type
OTHER

Study Record Dates

First Submitted

June 4, 2008

First Posted

June 6, 2008

Study Start

September 1, 2006

Last Updated

June 6, 2008

Record last verified: 2008-06

Locations

ES(1)