NCT00692055

Brief Summary

We will evaluate the bioavailability of naproxen 375 mg in two formulations

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at P25-P50 for phase_1

Timeline
Completed

Started Jun 2008

Shorter than P25 for phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2008

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

June 4, 2008

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 6, 2008

Completed
25 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
Last Updated

September 5, 2008

Status Verified

September 1, 2008

Enrollment Period

1 month

First QC Date

June 4, 2008

Last Update Submit

September 4, 2008

Conditions

Outcome Measures

Primary Outcomes (1)

  • To assess and compare the pharmacokinetics bioavailability of a single oral dose of naproxen administered in two formulations

    72-hour PK

Secondary Outcomes (1)

  • To evaluate the safety of the two treatments

    entire study duration

Study Arms (2)

1

EXPERIMENTAL

PN400

Drug: PN400

2

ACTIVE COMPARATOR

naproxen 375 mg

Drug: Naproxen

Interventions

PN400DRUG

naproxen 375 mg / esomeprazole 20 mg

1

naproxen 375 mg

2

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Unknown Facility

Austin, Texas, United States

Location

MeSH Terms

Conditions

Arthritis

Interventions

Naproxen

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Naphthaleneacetic AcidsNaphthalenesPolycyclic Aromatic HydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsPolycyclic Compounds

Study Design

Study Type
interventional
Phase
phase 1
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

June 4, 2008

First Posted

June 6, 2008

Study Start

June 1, 2008

Primary Completion

July 1, 2008

Study Completion

July 1, 2008

Last Updated

September 5, 2008

Record last verified: 2008-09

Locations