Trials Sponsors Conditions Drugs Pricing

Conditions

Central Centrifugal Scarring Alopecia Discoid Lupus Erythematosus Lichen Planopilaris

Keywords

alopecialupus

Outcome Measures

Primary Outcomes (1)

To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia (CCSA), lichen planopilaris (LP) and discoid lupus erythematosus (DLE) and in healthy controls.
8 weeks

Secondary Outcomes (1)

To evaluate the expression of Fas protein in skin biopsies of participants with central centrifugal scarring alopecia before and after treatment with intralesional and topical steroids.
8 weeks

Study Arms (3)

I

CCSA subjects will be recruited from patients who have been diagnosed through biopsy with CCSA and treated with standard of care for up to eight months in the Department of Dermatology clinic of Wake Forest University School of Medicine.

II

patients with lichen planopilaris (LP) and patients with discoid lupus erythematosus (DLE) will be collected from patients who have been diagnosed through biopsy in the clinic.

III

Healthy study subjects will be patients from the Wake Forest University School of Medicine Department of Dermatology population undergoing excisions for cosmetic purposes or excision of free margins around tumors that would have otherwise been discarded.

Eligibility Criteria

Age30 Years+

Sexfemale

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Wake Forest University Health Sciences Dermatology Clinic.

You may qualify if:

Participants ages 30 years or older with a biopsy- proven diagnosis of CCSA.

Sponsors & Collaborators

Wake Forest University
Otherlead

Study Sites (1)

Wake Forest University Health Sciences Dermatology

Winston-Salem, North Carolina, 27157, United States

Biospecimen

Retention: SAMPLES WITH DNA

Two, 4mm punch biopsies will be obtained of skin tissue.

MeSH Terms

Conditions

Lichen PlanusLupus Erythematosus, DiscoidAlopecia

Condition Hierarchy (Ancestors)

Lichenoid EruptionsSkin Diseases, PapulosquamousSkin DiseasesSkin and Connective Tissue DiseasesLupus Erythematosus, CutaneousConnective Tissue DiseasesHypotrichosisHair DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Officials

Amy McMichael, MD
Wake Forest University Health Sciences
PRINCIPAL INVESTIGATOR

Enrollment

8 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 2, 2008

First Posted

June 5, 2008

Study Start

April 26, 2006

Actual (reported)

Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (3)

I

II

III

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (3)

I

II

III

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations