Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
CGRP-2008
CGRP-induced Headache in Patients With Familial Hemiplegic Migraine, Migraine With Aura and Healthy Controls
1 other identifier
interventional
30
1 country
1
Brief Summary
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2008
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2008
CompletedFirst Submitted
Initial submission to the registry
May 28, 2008
CompletedFirst Posted
Study publicly available on registry
June 2, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2008
CompletedAugust 3, 2009
July 1, 2009
3 months
May 28, 2008
July 31, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Migraine and associated symptoms
0-14 h
Secondary Outcomes (1)
Migraine aura
0 - 14 h
Study Arms (3)
1
EXPERIMENTALMA-patients
2
EXPERIMENTALFHM-patients
3
ACTIVE COMPARATORHealthy controls
Interventions
Eligibility Criteria
You may qualify if:
- Diagnosis of familial hemiplegic migraine (IHS-classification criteria)
- Diagnosis of migraine with aura(IHS-classification criteria)
- Healthy controls
You may not qualify if:
- Patients and controls:
- A history of cerebrovascular disease and other CNS- disease
- A history of serious somatic and mental disease
- A history suggesting ischaemic heart disease
- A history of hypo- or hypertension
- Daily intake of medication apart from oral contraceptives
- Abuse of alcohol or medicine (opioid analgesics).
- Pregnant or breastfeeding women.
- On the study day:
- No intake of a simple analgesic in the previous 48 hours
- No headache in the previous 48 hours
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Danish Headache Centerlead
- EUROHEADcollaborator
Study Sites (1)
Danish Headache Center, University of Copenhagen, Faculty of Health Sciences, Department of Neurology, Glostrup Hospital
Glostrup, Copenhagen, 2600, Denmark
Related Publications (2)
Hansen JM, Thomsen LL, Olesen J, Ashina M. Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide. Cephalalgia. 2008 May;28(5):496-505. doi: 10.1111/j.1468-2982.2008.01559.x. Epub 2008 Mar 31.
PMID: 18384418BACKGROUNDHansen JM, Thomsen LL, Marconi R, Casari G, Olesen J, Ashina M. Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine. Cephalalgia. 2008 Apr;28(4):367-75. doi: 10.1111/j.1468-2982.2008.01542.x. Epub 2008 Feb 22.
PMID: 18294248BACKGROUND
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Jakob Møller Hansen, MD
Danish Headache Center
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 28, 2008
First Posted
June 2, 2008
Study Start
May 1, 2008
Primary Completion
August 1, 2008
Study Completion
August 1, 2008
Last Updated
August 3, 2009
Record last verified: 2009-07