F18-Flouride PET/CT in Acute Knee Injury

NCT00687921 | Unknown DMC

• 1 other identifier: TASMC-08-EE-118-CTIL
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

18F-fluoride is a positron-emitting bone-seeking agent with favorable pharmacokinetic properties. Its uptake mechanism resembles that of 99mTc-MDP. After IV administration, 18F-fluoride diffuses through the bone capillaries into the bone extracellular fluid (ECF). Its plasma clearance is more rapid than that of 99mTc-MDP and its single-passage extraction efficiency is higher. The fast blood clearance of 18F-fluoride results in a better target- to- background ratio. Bone uptake of 18F-fluoride is two-fold higher than that of 99mTc-MDP. Combining the favorable pharmacokinetic characteristics of 18F-fluoride with the high performance of PET technology, 18F-fluoride is a valuable imaging modality of the skeleton. There are only few manuscripts on the role of static 18F-fluoride PET for detection of lesions in patients referred for non-oncologic indications The purpose of the study is to prospectively assess the added value of Fluoride PET/CT in the clinical setting of acute knee injury. The findings of Fluoride PET/CT will be correlated with those found on arthroscopy and MRI which the currently used diagnostic techniques with a high, however, not perfect diagnostic accuracy regarding the issue of bone injury which is a critical component on the long term outcome after knee injury.

Conditions

Knee Injury

Keywords

Knee trauma; MRI; arthroscopy; Patients over the age of 18 who had knee trauma intent to or had MRI assessment scheduled for arthroscopy

Outcome Measures

Primary Outcomes (1)

• we will refer patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy. The compartments of the injured knee will be evaluated on each of the modalities.

  6 mounth

Study Arms (1)

A

patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy.

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients over the age of 18 who had knee trauma, intent to or had MRI assessment and are scheduled for arthroscopy

You may qualify if:

• patients over the age of 18 who had knee trauma

You may not qualify if:

• pregnancy
• age under 18 years

Sponsors & Collaborators

• Tel-Aviv Sourasky Medical Center: lead

Biospecimen

Retention: NONE RETAINED

not relevant

MeSH Terms

Conditions

Knee Injuries

Condition Hierarchy (Ancestors)

Leg Injuries; Wounds and Injuries

Study Officials

• Einat R. Even-Sapir, MD, PhD

  Tel-Aviv Sourasky Medical Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Einat Even-sapir, PhD, MD

CONTACT

972-3-697-3432; evensap@tasmc.health.gov.il

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: May 28, 2008
• First Posted: June 2, 2008
• Study Start: June 1, 2008
• Primary Completion: March 1, 2009
• Study Completion: June 1, 2009
• Last Updated: June 2, 2008

Record last verified: 2008-05