Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia

NCT00687024 | Completed

• 1 other identifier: 1000010634
• Study Type: observational
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Focal cortical dysplasia (FCD) is a common finding in epilepsy surgery in pediatric patients. Children with intractable epilepsy would have extensive tests to identify the cause of epilepsy; this includes MR brain, video EEG and magnetoencephalography (MEG). The white matter next to FCD is frequently found to be abnormal on pathology. Diffusion tensor imaging (DTI) can be used to study the abnormal white matter and the area that often extends beyond the area that is visible.

Conditions

Focal Cortical Dysplasia; Epilepsy

Keywords

Epilepsy; Magnetic Resonance Imaging; Magnetoencephalography

Outcome Measures

Primary Outcomes (1)

• Evaluate the subcortical white matter in the visualized MR abnormality as well as beyond the visualized MR abnormality but subjacent to the MEG dipoles

  Immediately after MEG

Interventions

Magnetoencephalography PROCEDURE

MEG will be performed on a whole head Omega 151-channel gradiometer system. At least 15 2-minute periods of spontaneous data are recorded. The sampling rate for data acquisition is 625Hz, with a bandpass filter of 3 to 70 Hz and a notch filter of 60Hz.

MR imaging PROCEDURE

MR imaging will be performed on a GE 1.5T system using a variety of sequences, including sagittal T1, axial T2, axial FLAIR, coronal dual echo, coronal FLAIR, axial 3D T2 frFSE and axial SPGR.

Diffusion Tensor Imaging PROCEDURE

Diffusion tensor imaging will be performed on the same scanner, using single shot diffusion-weighted echo planar imaging. Twenty-five 'xial contiguous slices are obtained aligned to the anterior commissure line to cover the whole brain, giving a total imaging time of 4min 40sec.

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children with suspected FCD presenting with intractable epilepsy for MRI \& MEG. The children will be identified from referral for clinical MRI scans.

You may qualify if:

• Children with intractable epilepsy with suspected FCD for MRI \& MEG

You may not qualify if:

• Children with contraindications to MRI such as those with pacemaker

Sponsors & Collaborators

• The Hospital for Sick Children: lead

Study Sites (1)

The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada

Location

MeSH Terms

Conditions

Focal Cortical Dysplasia; Epilepsy

Interventions

Magnetoencephalography; Magnetic Resonance Spectroscopy; Diffusion Tensor Imaging

Condition Hierarchy (Ancestors)

Malformations of Cortical Development, Group I; Malformations of Cortical Development; Nervous System Malformations; Nervous System Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Brain Diseases; Central Nervous System Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques; Spectrum Analysis; Chemistry Techniques, Analytical; Neuroimaging; Diagnostic Imaging; Diffusion Magnetic Resonance Imaging; Magnetic Resonance Imaging; Tomography

Study Officials

• Charles Raybaud, M.D.

  The Hospital for Sick Children

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Division Head, Neuroradiology

Study Record Dates

• First Submitted: May 26, 2008
• First Posted: May 30, 2008
• Study Start: May 1, 2007
• Primary Completion: June 1, 2013
• Study Completion: June 1, 2013
• Last Updated: September 5, 2013

Record last verified: 2013-09

Locations

CA (1)