NCT00686452

Brief Summary

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. 1.to compare the prevalence of asthma in swimmers and control subjects
  2. 2.to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
  3. 3.to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Mar 2007

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2007

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

May 26, 2008

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 29, 2008

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2009

Completed
Last Updated

December 22, 2008

Status Verified

May 1, 2008

Enrollment Period

2.2 years

First QC Date

May 26, 2008

Last Update Submit

December 18, 2008

Conditions

AsthmaAirway Hyperresponsiveness

Keywords

AsthmaAirway hyperresponsivenessSwimmersAirway inflammationAirway remodelling

Outcome Measures

Primary Outcomes (1)

  • Asthma and airway hyperreactivity prevalence in swimmers

    3 measurements in the year

Secondary Outcomes (1)

  • Airway inflammation and remodeling in swimmers

    3 measurements in the year and a bronchial biopsy

Study Arms (7)

1

Swimmers without AHR

2

Swimmers with asymptomatic AHR

3

Swimmers with symptomatic AHR and use only of beta-2 adrenargic

4

Swimmers with asthma and inhaled corticosteroids

5

Healthy Subjects

6

Healthy subjects with AHR

7

Healthy subjects with symptomatic AHR (asthma) but without treatment

Eligibility Criteria

Age14 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

You may qualify if:

  • to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

You may not qualify if:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval

Québec, Quebec, G1V4G5, Canada

RECRUITING

Related Publications (2)

  • Bougault V, Odashiro P, Turmel J, Orain M, Laviolette M, Joubert P, Boulet LP. Changes in airway inflammation and remodelling in swimmers after quitting sport competition. Clin Exp Allergy. 2018 Dec;48(12):1748-1751. doi: 10.1111/cea.13257. Epub 2018 Sep 14. No abstract available.

    PMID: 30141830DERIVED

  • Bougault V, Turmel J, Boulet LP. Bronchial challenges and respiratory symptoms in elite swimmers and winter sport athletes: Airway hyperresponsiveness in asthma: its measurement and clinical significance. Chest. 2010 Aug;138(2 Suppl):31S-37S. doi: 10.1378/chest.09-1689. Epub 2010 Apr 2.

    PMID: 20363843DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Serum, plasma, bronchial biopsies

MeSH Terms

Conditions

AsthmaRespiratory HypersensitivityAirway Remodeling

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesHypersensitivity, ImmediateHypersensitivityImmune System DiseasesPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Central Study Contacts

Valérie BOUGAULT, PhD

CONTACT

418-656-8711valerie.bougault@crhl.ulaval.ca

Louis-Philippe BOULET, MD

CONTACT

418-656-4747lpboulet@crhl.ulaval.ca

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 26, 2008

First Posted

May 29, 2008

Study Start

March 1, 2007

Primary Completion

May 1, 2009

Study Completion

May 1, 2009

Last Updated

December 22, 2008

Record last verified: 2008-05

Locations

CA(1)