The Significance of Low-Dose Aspirin on Ovarian Responsiveness, Uterine Hemodynamics and Pregnancy Outcome in in Vitro Fertilization and in Intracytoplasmic Sperm Injection: A Randomized, Placebo-Controlled Double-Blind Study
Sponsor study identifier
interventional
374
1 country
1
Study Start
March 2001
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2006
Actual (reported)Study Completion
March 2006
Actual (reported)In this study we hypothesized that low-dose aspirin therapy (100 mg daily) improves ovarian responsiveness, uterine haemodynamics and clinical pregnancy rates in unselected subjects undergoing IVF/ICSI when the treatment is started concomitantly with controlled ovarian hyperstimulation.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2006
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2001
Date type not reportedThis date has not been verified as actual or estimated.
March 2006
Actual (reported)March 2006
Actual (reported)May 21, 2008
Actual (reported)May 23, 2008
Actual (reported)Pregnancy rate
Five weeks after embryo transfer
Uterine artery and spiral artery pulsatility index values
On the day of embryo transfer
Acetylsalicylic acid 100 mg daily perorally
Placebo daily perorally
Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection
Acetylsalicylic acid 100 mg or placebo daily perorally started on the first day of ovarian gonadotrophin stimulation in in vitro fertilization or in intracytoplasmic sperm injection
University Hospital of Oulu, Department of Obstetrics and Gynecology
Oulu, 90220, Finland
Haapsamo M, Martikainen H, Tinkanen H, Heinonen S, Nuojua-Huttunen S, Rasanen J. Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study. Hum Reprod. 2010 Dec;25(12):2972-7. doi: 10.1093/humrep/deq286. Epub 2010 Oct 13.
Haapsamo M, Martikainen H, Rasanen J. Low-dose aspirin and uterine haemodynamics on the day of embryo transfer in women undergoing IVF/ICSI: a randomized, placebo-controlled, double-blind study. Hum Reprod. 2009 Apr;24(4):861-6. doi: 10.1093/humrep/den489. Epub 2009 Jan 18.
Mervi Haapsamo, MD
University Hospital of Oulu, Finland
Juha Rasanen, MD
University Hospital of Oulu, Finland and Oregon Health Sciences University, Oregon USA
Hannu Martikainen, MD
University Hospital of Oulu, Finland
Juha S Tapanainen, Prof
University Hospital of Oulu, Finland
374 participants (actual enrollment reported by the registry).
First Submitted
May 21, 2008
First Posted
May 23, 2008
Study Start
March 2001
Date type not reportedThis date has not been verified as actual or estimated.
Screening for Preeclampsia in Norway With Aspirin Discontinuation at 24-28 Weeks
Contact the study team to confirm eligibility.
Seppo Heinonen, Prof
University Hospital of Kuopio, Finland
Helena Tinkanen, MD
Unversity Hospital of Tampere, Finland
Primary Completion
March 2006
Actual (reported)Study Completion
March 2006
Actual (reported)Last Updated
May 23, 2008
Record last verified: 2001-03
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