NCT00680784

Brief Summary

The objective of this study is to demonstrate the multiple-dose efficacy and safety of HKT-500 for the treatment of ankle sprain.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
260

participants targeted

Target at P50-P75 for phase_3

Timeline
Completed

Started Apr 2008

Shorter than P25 for phase_3

Geographic Reach
1 country

30 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

May 16, 2008

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 20, 2008

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2008

Completed
Last Updated

June 4, 2015

Status Verified

May 1, 2015

Enrollment Period

7 months

First QC Date

May 16, 2008

Last Update Submit

May 12, 2015

Conditions

Keywords

sprainanklepain

Outcome Measures

Primary Outcomes (1)

  • Pain Assessment

    2 Weeks

Secondary Outcomes (1)

  • Safety Assessment

    2 Weeks

Study Arms (2)

HKT-500 Ketoprofen Topical Patch

EXPERIMENTAL

Randomized, double-blind, placebo-controlled, multicenter study in men and women 18 years of age or older who have a painful, acute, benign, ankle sprain of the lateral ligament(s) within the previous 48 hours.

Drug: HKT-500 Ketoprofen Topical Patch

Placebo Patch

PLACEBO COMPARATOR

Treatment with placebo patch

Other: Placebo Patch

Interventions

HKT-500 Ketoprofen Topical Patch

Also known as: Ketoprofen Topical Patch
HKT-500 Ketoprofen Topical Patch

Placebo Patch

Also known as: Sham treatment
Placebo Patch

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Grade I or Grade II Ankle Sprain.

You may not qualify if:

  • The subject is a women of childbearing potential who has a positive urine pregnancy test, who is lactating, who is not surgically sterile (by tubal ligation or hysterectomy), or at least 2 years postmenopausal, and has not practice an acceptable form of birth control (defined as the use of an intrauterine device with spermicide, a barrier method with spermicide, condoms with spermicide, subdermal implant, oral contraceptives, or abstinence) for at least 2 months prior to Visit 1.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (30)

Hisamitsu Investigator Site.

Birmingham, Alabama, 35209, United States

Location

Hisamitsu Investigator Site.

Birmingham, Alabama, 35234, United States

Location

Hisamitsu Investigator Site.

Montgomery, Alabama, 36106, United States

Location

Hisamitsu Investigator Site.

Anaheim, California, 92804, United States

Location

Hisamitsu Investigator Site.

San Luis Obispo, California, 93405, United States

Location

Hisamitsu Investigator Site.

Colorado Springs, Colorado, 80909, United States

Location

Hisamitsu Investigator Site.

Kissimmee, Florida, 34741, United States

Location

Hisamitsu Investigator Site.

Oldsmar, Florida, 34677, United States

Location

Hisamitsu Investigator Site.

Pembroke Pines, Florida, 33026, United States

Location

Hisamitsu Investigator Site.

South Miami, Florida, 33143, United States

Location

Hisamitsu Investigator Site.

Blue Ridge, Georgia, 30513, United States

Location

Hisamitsu Investigator Site.

Chicago, Illinois, 60616, United States

Location

Hisamitsu Investigator Site.

Paducah, Kentucky, 42003, United States

Location

Hisamitsu Investigator Site.

Pasadena, Maryland, 21122, United States

Location

Hisamitsu Investigator Site.

Benzonia, Michigan, 49616, United States

Location

Hisamitsu Investigator Site.

Cadillac, Michigan, 49601, United States

Location

Hisamitsu Investigator Site.

Interlochen, Michigan, 49643, United States

Location

Hisamitsu Investigator Site.

Kalamazoo, Michigan, 49009, United States

Location

Hisamitsu Investigator Site.

Omaha, Nebraska, 68114, United States

Location

Hisamitsu Investigator Site.

South Bound Brook, New Jersey, 08880, United States

Location

Hisamitsu Investigator Site.

Albuquerque, New Mexico, 87102, United States

Location

Hisamitsu Investigator Site.

New York, New York, 10022, United States

Location

Hisamitsu Investigator Site.

Fargo, North Dakota, 58103, United States

Location

Hisamitsu Investigator Site.

Zanesville, Ohio, 43701, United States

Location

Hisamitsu Investigator Site.

Altoona, Pennsylvania, 16602, United States

Location

Hisamitsu Investigator Site.

Feasterville, Pennsylvania, 19053, United States

Location

Hisamitsu Investigator Site.

Morrisville, Pennsylvania, 19067, United States

Location

Hisamitsu Investigator Site.

Norristown, Pennsylvania, 19401, United States

Location

Hisamitsu Investigator Site.

Houston, Texas, 77074, United States

Location

Hisamitsu Investigator Site.

Bellevue, Washington, 98004, United States

Location

MeSH Terms

Conditions

Ankle InjuriesSprains and StrainsPain

Condition Hierarchy (Ancestors)

Leg InjuriesWounds and InjuriesNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Kenichi Furuta

    Hisamitsu Pharmaceutical Co., Inc.

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 16, 2008

First Posted

May 20, 2008

Study Start

April 1, 2008

Primary Completion

November 1, 2008

Study Completion

November 1, 2008

Last Updated

June 4, 2015

Record last verified: 2015-05

Locations