Development of a Family-Based Treatment for Adolescent Methamphetamine Use

NCT00680511 | Completed Phase 1

• 1 other identifier: DA021695
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The AIMS study compares a methamphetamine-specific treatment intervention to a treatment-as-usual Functional Family Therapy (FFT) approach for adolescents ages 15 to 19. Adolescents are assigned to one of two treatment conditions: (1) 16 weeks of FFT designed to strengthen family relationships and develop skills for helping the adolescent avoid drug use; or (2) 16 weeks of a combination of FFT and a methamphetamine-specific intervention involving group and individual therapy sessions; Families are assessed using questionnaires and interviews, and adolescents participate in neuropsychological testing, before, during, and after treatment to provide information about family functioning, the adolescent's drug use, the adolescent's peers, and other factors that may contribute to treatment success. Adolescents also provide urine specimens for drug screening at assessment visits. Through a partnership with Oregon Health and Science University (OHSU), adolescents will participate in functional magnetic resonance imaging appointments at the hospital to examine regional brain blood flow during tasks designed to measure impulsivity and risk-taking behaviors. As a treatment development grant, study investigators will study adolescents' acceptance of and response to the newly developed methamphetamine-specific treatment approach.

Conditions

Behavior and Mental Disorders; Methamphetamine Disorders

Keywords

methamphetamine abuse

Outcome Measures

Primary Outcomes (1)

• Substance Use

  6 months

Secondary Outcomes (1)

• Engagement and retention of adolescent methamphetamine users.

  6 months

Study Arms (2)

1

ACTIVE COMPARATOR

Family therapy combined with methamphetamine-specific group treatment.

Behavioral: Adolescent Methamphetamine Treament (AMT)

2

ACTIVE COMPARATOR

Family Therapy.

Behavioral: Functional Family Therapy (FFT)

Interventions

Adolescent Methamphetamine Treament (AMT) BEHAVIORAL

AMT Group Therapy plus Functional Family Therapy (FFT)

1

Functional Family Therapy (FFT) BEHAVIORAL

FFT

2

Eligibility Criteria

• Age: 15 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• to 19 years of age.
• Have at least one parent or parent figure willing to participate.
• Meet DSM-IV diagnostic criteria for drug-abuse or dependence, including a specific meth use disorder.
• Reports meth use on at least 5 of the previous 90 days.
• Have contact with the parent on at least 40% of the past 90 days.
• With their parent be willing to accept randomization to one of the two treatment interventions.
• Be willing to participate in the imaging task in the fMRI pilot study.
• Have basic English competency.
• Have sufficient residential stability to permit probable contact at follow-up.

You may not qualify if:

• Evidence of psychotic or organic state of sufficient severity to interfere with understanding of study instruments and procedures.
• Have a medical or psychological condition that would preclude undergoing the fMRI scan.
• Have a sibling who is participating in the study.

Sponsors & Collaborators

• Oregon Research Institute: lead
• National Institute on Drug Abuse (NIDA): collaborator

Study Sites (1)

Oregon Research Institute Center for Family and Adolescent Research

Portland, Oregon, 97205, United States

Location

MeSH Terms

Conditions

Behavior; Mental Disorders

Study Officials

• Holly B. Waldron, Ph.D.

  Oregon Research Institute

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2008
• First Posted: May 20, 2008
• Study Start: September 1, 2007
• Primary Completion: September 1, 2013
• Study Completion: December 1, 2013
• Last Updated: August 5, 2014

Record last verified: 2014-08

Locations

US (1)