Infectious Causes of Uveitis

NCT00676624 | Completed DMC

• 1 other identifier: H-B-2007-097
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Uveitis is an inflammatory disease of one or both eyes. Uveitis will in severe cases lead to permanent loss of vision/blindness on the affected eye. Uveitis can be caused by autoimmune disease, infections and rarely trauma, but 50 % of the cases remain of unknown origin. Intraocular infections are from previous studies, known to be responsible for approximately 40 % of the cases of severe forms of uveitis. Most infectious causes of uveitis have the potential to be treated with antibiotic. Most infectious causes of uveitis are under normal condition only possible to detect by using very specific detection methods. Further more it is often necessary to study a sample from with-in the eye (vitrectomy to get a proper diagnosis. The knowledge about witch kind of infections that causes uveitis, are therefore limited to the kind of infections that are tested for. Our hypothesis are that infections are a frequent cause of severe uveitis in Denmark, and that by using a broad diagnostic approach it is possible to identify new or less recognized infections agents that are associated with uveitis. By this study we want to describe the prevalence and distribution of infections among patients with severe uveitis. In this study are we only including patients with a severe form of uveitis from a referral-hospital setting, where vitrectomy is done for a diagnostic purpose. The patients will undergo a standard diagnostic examination including the most common infectious causes of uveitis. Beside this we will look for a broad range of infection, which has previously been described in the litera-ture to cause uveitis, but are not normally tested for. Further more, we will use broad ranged molecular diagnostic methods to look for new previously unknown bacterial causes of uveitis. Such study has not previously been done previously in Denmark. As control group are included patients that undergo vitrectomy for due either one of the two diseases "epiretinal fibrosis or "macula hole". All patients and controls will be interview using a standardized questionnaire about risk factors for acquiring these infections.

Conditions

Uveitis

Keywords

uveitis; vitrectomy; infection; severe

Outcome Measures

Primary Outcomes (1)

• Prevalence and distribution of intraocular infections in the study group

  September 2010

Secondary Outcomes (1)

• The value of non-specific molecular diagnostic methods for detection of bacteria in the study group

  September 2010

Study Arms (2)

Uveitis

Patients suffering from uveitis, who have vitrectomy performed for diagnostic purpose

Control group

Patients suffering from either "Epiretinal fibrosis" og "Macula hole" who have vitrectomy performed for curative reasons

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient at a referal hospital eye clinic with uveitis were vitrectomy will be performed for diagnostic reasons

You may qualify if:

• Patient at Glostrup Hospital refferal eye clinic with uveitis were vitrectomy will be performed for diagnostic reasons

You may not qualify if:

• patients where eye surgery has been performed on the affected eye, within 30 days before the current vitrectomy
• Patients with known lymphoma
• Patient with clinical suspicion of intra-ocular cancer disease
• Pregnant and lactating women

Sponsors & Collaborators

• Statens Serum Institut: lead
• Glostrup University Hospital, Copenhagen: collaborator
• University of Copenhagen: collaborator

Study Sites (1)

Glostrup Hospital

Glostrup Municipality, 2600, Denmark

Location

Related Publications (1)

• Bodaghi B, Cassoux N, Wechsler B, Hannouche D, Fardeau C, Papo T, Huong DL, Piette JC, LeHoang P. Chronic severe uveitis: etiology and visual outcome in 927 patients from a single center. Medicine (Baltimore). 2001 Jul;80(4):263-70. doi: 10.1097/00005792-200107000-00005. No abstract available.

  PMID: 11470987 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Corpus vitreum (vitreus body) Aqua from the anterior champer Whole blood in dry container Whole blood in container containing EDTA Whole blood in QuantiFERON test KIT for tuberculosis Urine

MeSH Terms

Conditions

Uveitis; Infections; Lymphoma, Follicular

Condition Hierarchy (Ancestors)

Uveal Diseases; Eye Diseases; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Steen Villumsen, MD PhD stud

  Statens Serum Institut

  PRINCIPAL INVESTIGATOR

• Morten la Cour, MD DMSc

  Glostrup University Hospital, Copenhagen

  STUDY CHAIR

• Karen A Krogfelt, Prof. PhD

  Statens Serum Institut

  STUDY CHAIR

• Helle J Fuchs, MD

  Glostrup University Hospital, Copenhagen

  STUDY CHAIR

• Jan U Prause, MD Prof DMSC

  University of Copenhagen

  STUDY CHAIR

• Henrik V Nielsen, PhD

  Statens Serum Institut

  STUDY CHAIR

• Lars P Nielsen, MD

  Statens Serum Institut

  STUDY CHAIR

• Vibeke Thomsen, Cand Scient

  Statens Serum Institut

  STUDY CHAIR

• Anne-Mette Lebech, MD, DMSc

  Hvidovre University Hospital

  STUDY CHAIR

• Jorgen S Jensen, MD DMSc

  Statens Serum Institut

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD

Study Record Dates

• First Submitted: May 8, 2008
• First Posted: May 13, 2008
• Study Start: April 1, 2008
• Primary Completion: September 1, 2010
• Study Completion: September 1, 2010
• Last Updated: May 15, 2014

Record last verified: 2014-05

Locations

DK (1)