Phase 2 Study in Adults Sensitized to Short Ragweed

NCT00670384 | Withdrawn Phase 2

• 1 other identifier: ALI001-08
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to identify an effective dose of allergen-specific immunotherapy for short ragweed (Ambrosia artemisiifolia) administered by an oral/sublingual route.

Conditions

Allergic Rhinitis

Keywords

SLIT; Immunotherapy; Short ragweed; SAR; Seasonal allergic rhinitis

Outcome Measures

Primary Outcomes (1)

• Average of Total Symptom Scores

  20 weeks

Study Arms (3)

Dose Group A

ACTIVE COMPARATOR

Standardized Allergenic Extract, Short Ragweed (Ambrosia artemisiifolia)

Biological: Standardized Allergenic Extract, Short Ragweed (Ambrosia artemisiifolia)

Dose Group B

ACTIVE COMPARATOR

Standardized Allergenic Extract, Short Ragweed (Ambrosia artemisiifolia)

Biological: Standardized Allergenic Extract, Short Ragweed (Ambrosia artemisiifolia)

Placebo

PLACEBO COMPARATOR

Biological: Placebo

Interventions

Standardized Allergenic Extract, Short Ragweed (Ambrosia artemisiifolia) BIOLOGICAL

Sublingual drops

Dose Group A; Dose Group B

Placebo BIOLOGICAL

Sublingual drops

Placebo

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male and female patients between the ages of 18 and 55 years (inclusive.
• Written informed consent to participate in the study.
• Documented allergy to short ragweed pollen as demonstrated by a positive epicutaneous skin test (wheal \>3 mm) and symptoms of allergic rhinitis during the two previous short ragweed seasons.
• Female subjects of childbearing potential, defined as not surgically sterile or at least 2 years postmenopausal, must agree to use one of the following forms of contraception from screening through the 4 week follow-up period following the last dose of Clinical Trial Material (CTM): hormonal (oral, implant, or injection) begun \>30 days prior to screening, barrier (condom, diaphragm with spermicide), Intrauterine Device (IUD), or vasectomized partner (6 months minimum).
• No clinically significant abnormal findings on the physical examination, with the exception of head, eyes, ears, nose and throat (HEENT) findings consistent with allergic rhinitis, medical history, or clinical laboratory results during screening which, in the opinion of the Investigator, would jeopardize the safety of the subject or impact the validity of the study results

You may not qualify if:

• Previous allergen immunotherapy (subcutaneous immunotherapy (SCIT), oral immunotherapy, sublingual immunotherapy (SLIT), or recombinant peptide) for short ragweed within 24 months of the Screening Visit.
• History of severe allergic reaction requiring medical intervention.
• Intolerance of or severe allergic reaction to previous immunotherapy (SCIT, oral immunotherapy, SLIT, or recombinant peptide).
• Allergy to any of the non-antigen ingredients in the study drug formulation, including, but not limited to, Food, Drug and Cosmetic (FD\&C) Yellow #5, sodium chloride, sodium bicarbonate, and glycerine.
• History of asthma requiring daily medication.
• Subjects receiving anti-IgE monoclonal antibodies.
• Congenital immune deficiency or acquired immune suppression. Causes of acquired immune suppression may include, but are not limited to, systemic illnesses such as malignancy and infection, the use of medications such as corticosteroids and chemotherapeutic agents, and radiation therapy.
• History of organ transplant, hematologic malignancy, autoimmune disease, myocardial infarction, or congestive heart failure.
• History of clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, psychiatric, or cardiovascular disease, or any other condition which, in the opinion of the Investigator, would jeopardize the safety of the subject or impact the validity of the study results.
• Inability or unwillingness to stop using drugs that may inhibit the wheal-and-flare reaction or rhinitic response prior to the study and for the duration of dosing CTM (with the exception of protocol-specified rescue medications provided by the study site for use after Study Day 0).
• Inability or unwillingness to stop using drugs that may inhibit the ability to treat a severe allergic adverse event. This includes, but is not limited to: beta blockers such as atenolol (Tenormin), metoprolol (Lopressor, Toprol-XL) and propranolol (Inderal, Inderal LA) for 14 days prior to Study Day 0 and for the duration of the study
• Female subjects who are trying to conceive, are pregnant, or are lactating.
• Positive serum pregnancy test at screening or a positive human chorionic gonadotropin (HCG) urine test on Study Day 0 prior to administration of study drug for women of childbearing potential.
• Positive blood screen for HIV, Hepatitis B surface antigen (HbSAg), or Hepatitis C.
• History of alcohol or drug abuse within the year prior to the Screening Visit, or current evidence of substance dependence or abuse.

Sponsors & Collaborators

• Antigen Laboratories, Inc.: lead

MeSH Terms

Conditions

Rhinitis, Allergic; Rhinitis, Allergic, Seasonal

Condition Hierarchy (Ancestors)

Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 29, 2008
• First Posted: May 1, 2008
• Last Updated: January 9, 2014

Record last verified: 2014-01